HKDC1
HKDC1，即含己糖激酶結(jié)構(gòu)域1，別名RP92。HKDC1由人類HKDC1基因編碼，該基因位于10號染色體的q22.1區(qū)域。HKDC1編碼的蛋白質(zhì)屬于己糖激酶蛋白家族，參與葡萄糖代謝。HKDC1的作用機制涉及其在葡萄糖代謝中的活性，盡管其葡萄糖磷酸化活性相對較低，但它可能具有除了典型己糖激酶活性之外的“兼職”功能。HKDC1的表達減少可能與妊娠糖尿病有關(guān)，而其高表達可能與肝癌的不良預(yù)后相關(guān)。HKDC1在某些癌癥中的異常表達與患者總體生存密切相關(guān)，表明其可能在癌癥進展中發(fā)揮作用。HKDC1還可能通過與細胞骨架的耦合激活STAT1并增強PD-L1表達，從而促進腫瘤免疫逃逸。HKDC1被認為是癌癥治療的潛在靶點，尤其是在肝癌和肺癌的治療中。
熱銷產(chǎn)品
HKDC1 Antibody (CSB-PA647983LA01HU)
驗證數(shù)據(jù)
Western blot
All lanes: HKDC1 antibody at 4µg/ml + U87 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 103, 91, 83 kDa
Observed band size: 103 kDa
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA647983LA01HU at dilution of 1:100
HKDC1 Antibodies
HKDC1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA647983LA01HU | HKDC1 Antibody | Human | ELISA, WB, IHC |
| CSB-PA647983LB01HU | HKDC1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA647983LC01HU | HKDC1 Antibody, FITC conjugated | Human | |
| CSB-PA647983LD01HU | HKDC1 Antibody, Biotin conjugated | Human | ELISA |
HKDC1 Proteins
HKDC1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP647983HU CSB-EP647983HU CSB-BP647983HU CSB-MP647983HU CSB-EP647983HU-B |
Recombinant Human Hexokinase HKDC1 (HKDC1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HKDC1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP852780MO CSB-EP852780MO CSB-BP852780MO CSB-MP852780MO CSB-EP852780MO-B |
Recombinant Mouse Putative hexokinase HKDC1 (Hkdc1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
