HLA-A
HLA-A，全稱(chēng)為人類(lèi)白細(xì)胞抗原A類(lèi)分子，是人體免疫系統(tǒng)中的關(guān)鍵成分，負(fù)責(zé)識(shí)別和提呈抗原給T細(xì)胞，從而啟動(dòng)免疫應(yīng)答。它屬于MHC-I類(lèi)分子，廣泛表達(dá)于各類(lèi)有核細(xì)胞表面，尤其在淋巴細(xì)胞中表達(dá)量最高。HLA-A蛋白與B2M蛋白結(jié)合形成異二聚體，共同構(gòu)成抗原提呈復(fù)合物，能夠識(shí)別并提呈內(nèi)源性抗原肽給CD8+ T細(xì)胞，引發(fā)細(xì)胞毒性T細(xì)胞的產(chǎn)生，清除感染或異常細(xì)胞。此外，HLA-A蛋白還能與NK細(xì)胞上的KIR結(jié)合，調(diào)節(jié)NK細(xì)胞的殺傷活性。在疾病方面，HLA-A蛋白的多態(tài)性與多種自身免疫性疾病和藥物不良反應(yīng)相關(guān)，如銀屑病、類(lèi)風(fēng)濕性關(guān)節(jié)炎等。在藥物研發(fā)領(lǐng)域，HLA-A蛋白被廣泛應(yīng)用于T細(xì)胞免疫治療，如CAR-T和TCR-T療法，通過(guò)改造T細(xì)胞的HLA-A分子，使其能夠特異性識(shí)別腫瘤細(xì)胞，從而實(shí)現(xiàn)精準(zhǔn)治療。
熱銷(xiāo)產(chǎn)品
HLA-A Recombinant Monoclonal Antibody (CSB-RA977288A0HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: A549 whole cell lysate(30μg), HEK293 whole cell lysate(30μg), HepG2 whole cell lysate(30μg), PC-3 whole cell lysate(30μg)
All lanes: HLA-A antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 41 kDa
Observed band size: 41 kDa
Exposure time: 2min
Overlay Peak curve showing jurkat cells stained with CSB-RA977288A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for?10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
HLA-A Antibodies
HLA-A for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-RA977288A0HU | HLA-A Recombinant Monoclonal Antibody | Human | ELISA, WB, FC |
HLA-A Proteins
HLA-A Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP318036HU CSB-EP318036HU CSB-BP318036HU CSB-MP318036HU CSB-EP318036HU-B |
Recombinant Human HLA class I histocompatibility antigen, A-32 alpha chain (HLA-A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP318407HU CSB-EP318407HU CSB-BP318407HU CSB-MP318407HU CSB-EP318407HU-B |
Recombinant Human HLA class I histocompatibility antigen, A-11 alpha chain (HLA-A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP319883HU CSB-EP319883HU CSB-BP319883HU CSB-MP319883HU CSB-EP319883HU-B |
Recombinant Human HLA class I histocompatibility antigen, A-69 alpha chain (HLA-A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP322266HU CSB-EP322266HU CSB-BP322266HU CSB-MP322266HU CSB-EP322266HU-B |
Recombinant Human HLA class I histocompatibility antigen, A-33 alpha chain (HLA-A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP323682HU CSB-EP323682HU CSB-BP323682HU CSB-MP323682HU CSB-EP323682HU-B |
Recombinant Human HLA class I histocompatibility antigen, A-31 alpha chain (HLA-A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP325409HU CSB-EP325409HU CSB-BP325409HU CSB-MP325409HU CSB-EP325409HU-B |
Recombinant Human HLA class I histocompatibility antigen, A-30 alpha chain (HLA-A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP325985HU CSB-EP325985HU CSB-BP325985HU CSB-MP325985HU CSB-EP325985HU-B |
Recombinant Human HLA class I histocompatibility antigen, A-25 alpha chain (HLA-A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP326974HU CSB-EP326974HU CSB-BP326974HU CSB-MP326974HU CSB-EP326974HU-B |
Recombinant Human HLA class I histocompatibility antigen, A-36 alpha chain (HLA-A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP328989HU CSB-MP328989HU CSB-EP328989HU-B |
Recombinant Human HLA class I histocompatibility antigen, A alpha chain (HLA-A), partial | Yeast Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP328994HU CSB-EP328994HU CSB-BP328994HU CSB-MP328994HU CSB-EP328994HU-B |
Recombinant Human HLA class I histocompatibility antigen, A-29 alpha chain (HLA-A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP329996HU CSB-EP329996HU CSB-BP329996HU CSB-MP329996HU CSB-EP329996HU-B |
Recombinant Human HLA class I histocompatibility antigen, A-34 alpha chain (HLA-A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP333529HU CSB-EP333529HU CSB-BP333529HU CSB-MP333529HU CSB-EP333529HU-B |
Recombinant Human HLA class I histocompatibility antigen, A-26 alpha chain (HLA-A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP335547HU CSB-EP335547HU CSB-BP335547HU CSB-MP335547HU CSB-EP335547HU-B |
Recombinant Human HLA class I histocompatibility antigen, A-23 alpha chain (HLA-A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP335548HU CSB-EP335548HU CSB-BP335548HU CSB-MP335548HU CSB-EP335548HU-B |
Recombinant Human HLA class I histocompatibility antigen, A-74 alpha chain (HLA-A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP339100HU CSB-EP339100HU CSB-BP339100HU CSB-MP339100HU CSB-EP339100HU-B |
Recombinant Human HLA class I histocompatibility antigen, A-66 alpha chain (HLA-A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP341151HU CSB-EP341151HU CSB-BP341151HU CSB-MP341151HU CSB-EP341151HU-B |
Recombinant Human HLA class I histocompatibility antigen, A-43 alpha chain (HLA-A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP356256HU CSB-EP356256HU CSB-BP356256HU CSB-MP356256HU CSB-EP356256HU-B |
Recombinant Human HLA class I histocompatibility antigen, A-3 alpha chain (HLA-A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP360790HU CSB-EP360790HU CSB-BP360790HU CSB-MP360790HU CSB-EP360790HU-B |
Recombinant Human HLA class I histocompatibility antigen, A-2 alpha chain (HLA-A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP361548HU CSB-EP361548HU CSB-BP361548HU CSB-MP361548HU CSB-EP361548HU-B |
Recombinant Human HLA class I histocompatibility antigen, A-24 alpha chain (HLA-A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP365680HU CSB-EP365680HU CSB-BP365680HU CSB-MP365680HU CSB-EP365680HU-B |
Recombinant Human HLA class I histocompatibility antigen, A-68 alpha chain (HLA-A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP600599HU CSB-EP600599HU CSB-BP600599HU CSB-MP600599HU CSB-EP600599HU-B |
Recombinant Human HLA class I histocompatibility antigen, A-80 alpha chain (HLA-A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP328989HU | Recombinant Human HLA class I histocompatibility antigen, A alpha chain (HLA-A), partial | E.coli |
| CSB-EP328989HUb1 | Recombinant Human HLA class I histocompatibility antigen, A alpha chain (HLA-A), partial | E.coli |
| CSB-BP328989HU | Recombinant Human HLA class I histocompatibility antigen, A alpha chain (HLA-A), partial | Baculovirus |
