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HNF4A

HNF4A,即肝細(xì)胞核因子4α,別名NR2A1、TCF14、MODY1。HNF4A是一種核受體超家族成員,屬于配體依賴性轉(zhuǎn)錄因子,主要分布在肝臟中,在肝臟的發(fā)育和肝細(xì)胞分化成熟過(guò)程中起重要調(diào)控作用。HNF4A在轉(zhuǎn)錄水平上調(diào)控肝臟特異基因的表達(dá),促進(jìn)肝細(xì)胞的發(fā)育和分化,參與肝細(xì)胞極性的建立和維持,增強(qiáng)肝臟的合成、代謝及解毒功能。HNF4A通過(guò)抑制肝星狀細(xì)胞的活化、逆轉(zhuǎn)上皮間質(zhì)細(xì)胞轉(zhuǎn)化、抑制肝癌細(xì)胞增殖、侵襲和轉(zhuǎn)移等機(jī)制,參與肝纖維化、肝硬化和肝細(xì)胞癌等疾病的發(fā)生和變化過(guò)程。HNF4A的表達(dá)異常與多種肝臟疾病相關(guān),包括肝纖維化、肝硬化和肝癌。

熱銷產(chǎn)品

Recombinant Human Hepatocyte nuclear factor 4-alpha (HNF4A) (CSB-EP010594HU)

驗(yàn)證數(shù)據(jù)

CSB-EP010594HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP010594HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) HNF4A.

CSB-EP010594HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP010594HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) HNF4A.

HNF4A Recombinant Monoclonal Antibody (CSB-RA571090A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA571090A0HU

Western Blot
Positive WB detected in: HL-60 whole cell lysate, Rat Liver tissue lysate,
All lanes: HNF-4-alpha antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 52 kDa
Observed band size: 52 kDa

CSB-RA571090A0HU

IHC image of CSB-RA571090A0HU diluted at 1:50 and staining in paraffin-embedded human gastric cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.75% DAB.

CSB-RA571090A0HU

Immunofluorescence staining of MCF-7 with CSB-RA571090A0HU at 1:20, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 526-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CSB-RA571090A0HU

Overlay Peak curve showing HepG2 cells stained with CSB-RA571090A0HU (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

HNF4A Antibodies

HNF4A for Homo sapiens (Human)

HNF4A Proteins

HNF4A Proteins for Rattus norvegicus (Rat)

HNF4A Proteins for Homo sapiens (Human)

HNF4A Proteins for Mus musculus (Mouse)

HNF4A Proteins for Xenopus laevis (African clawed frog)