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HSP90AB1

HSP90AB1,即熱休克蛋白90α家族B類(lèi)成員1,別名HSP84、HSPC2、HSPCB、D6S182、HSP90B等。HSP90AB1由人類(lèi)HSP90AB1基因編碼,該基因位于6號(hào)染色體的p21.1區(qū)域。HSP90AB1是一種分子伴侶蛋白,屬于熱休克蛋白90家族,參與信號(hào)轉(zhuǎn)導(dǎo)、蛋白質(zhì)折疊和降解以及形態(tài)進(jìn)化。HSP90AB1在細(xì)胞內(nèi)與多種蛋白質(zhì)相互作用,影響多個(gè)生物學(xué)過(guò)程,包括對(duì)載肽的MHC1復(fù)合體在精子細(xì)胞中的成熟、hERG離子通道成熟過(guò)程中的處理以及對(duì)KCNQ4通道的生物生成和內(nèi)皮一氧化氮合酶(eNOS)活性的調(diào)控。此外,HSP90AB1還參與分泌型外泌體的釋放,促進(jìn)傷口愈合和炎癥反應(yīng)。在癌癥中,這些功能可被癌細(xì)胞利用,從而促進(jìn)其侵襲和轉(zhuǎn)移。HSP90AB1的高表達(dá)與多種癌癥類(lèi)型的不良預(yù)后顯著相關(guān),使其成為癌癥治療的一個(gè)重要靶點(diǎn)。

熱銷(xiāo)產(chǎn)品

Recombinant Human Heat shock protein HSP 90-beta (HSP90AB1) (CSB-EP010808HU)

驗(yàn)證數(shù)據(jù)

CSB-EP010808HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-EP010808HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP010808HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) HSP90AB1.

CSB-EP010808HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP010808HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) HSP90AB1.

HSP90AB1 Recombinant Monoclonal Antibody (CSB-RA644510A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA644510A0HU

IHC image of CSB-RA644510A0HU diluted at 1:50 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.74% DAB.

CSB-RA644510A0HU

IHC image of CSB-RA644510A0HU diluted at 1:50 and staining in paraffin-embedded human rectal cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.74% DAB.

CSB-RA644510A0HU

Overlay Peak curve showing Hela cells stained with CSB-RA644510A0HU (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

Human Heat shock protein HSP 90-beta(HSP90AB1) ELISA kit (CSB-EL010808HU)

驗(yàn)證數(shù)據(jù)

CSB-EL010808HU 標(biāo)準(zhǔn)曲線

貨號(hào):CSB-EL010808HU

規(guī)格:96T/48T

靈敏度:0.39 ng/mL

檢測(cè)范圍:1.56 ng/mL-100 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

HSP90AB1 Antibodies

HSP90AB1 for Homo sapiens (Human)

HSP90AB1 for H, M, R

HSP90AB1 Proteins

HSP90AB1 Proteins for Mus musculus (Mouse)

HSP90AB1 Proteins for Oryctolagus cuniculus (Rabbit)

HSP90AB1 Proteins for Homo sapiens (Human)

HSP90AB1 Proteins for Rattus norvegicus (Rat)

HSP90AB1 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

HSP90AB1 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

HSP90AB1 Proteins for Pongo abelii (Sumatran orangutan)

HSP90AB1 Proteins for Bos taurus (Bovine)

HSP90AB1 Proteins for Equus caballus (Horse)

HSP90AB1 ELISA Kit

HSP90AB1 ELISA Kit for Homo sapiens (Human)

HSP90AB1 ELISA Kit for Mus musculus (Mouse)