HSP90B1
HSP90B1，全稱為熱休克蛋白90kDa beta亞家族成員1，在人體內(nèi)廣泛存在，也被稱為endoplasmin、gp96、GRP94或ERp99。它是一種分子伴侶蛋白，主要位于內(nèi)質(zhì)網(wǎng)中，在蛋白質(zhì)的折疊、轉(zhuǎn)運(yùn)和組裝過程中發(fā)揮著關(guān)鍵作用。HSP90B1能夠幫助蛋白質(zhì)正確折疊，并保護(hù)它們免受損傷，從而維持細(xì)胞的正常功能。此外，HSP90B1還參與免疫調(diào)節(jié)，并被認(rèn)為是腫瘤免疫治療的重要靶點(diǎn)。
HSP90B1與多種疾病密切相關(guān)，包括癌癥、自身免疫性疾病和神經(jīng)退行性疾病等。在癌癥治療中，HSP90B1已被證明是多種癌癥免疫治療藥物的靶點(diǎn)。例如，vitespen（HSP90B1的腫瘤衍生形式）已被用于治療黑色素瘤。此外，研究人員正在開發(fā)針對HSP90B1的抑制劑，以治療癌癥和其他疾病。
在藥物研發(fā)方面，HSP90B1已成為一個重要的靶點(diǎn)。由于HSP90B1在維持細(xì)胞內(nèi)蛋白質(zhì)穩(wěn)態(tài)方面發(fā)揮著關(guān)鍵作用，因此抑制HSP90B1可能有助于治療多種疾病。目前，已有多種針對HSP90B1的抑制劑進(jìn)入臨床試驗(yàn)階段，用于治療癌癥、自身免疫性疾病和神經(jīng)退行性疾病等。
熱銷產(chǎn)品
Recombinant Human Endoplasmin (HSP90B1), partial (CSB-EP010814HU1)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-RP108894h could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) HSP90B1.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-RP108894h could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) HSP90B1.
HSP90B1 Antibody (CSB-PA002347)
驗(yàn)證數(shù)據(jù)
Western Blot analysis of HeLa cells using Endoplasmin Polyclonal Antibody
Western Blot analysis of K562 cells using Endoplasmin Polyclonal Antibody
Human Heat Shock Protein glycoprotein 96,HSP gp96 ELISA Kit (CSB-E08551h)
驗(yàn)證數(shù)據(jù)
貨號：CSB-E08551h
規(guī)格：96T/48T
靈敏度：0.156 ng/mL
檢測范圍：0.625 ng/mL-40 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
HSP90B1 Antibodies
HSP90B1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA010814GA01HU | HSP90B1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA10887A0Rb | HSP90B1 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA10887C0Rb | HSP90B1 Antibody, FITC conjugated | Human | |
| CSB-PA002347 | HSP90B1 Antibody | Human,Mouse | WB, IHC, IF, ELISA |
| CSB-PA179036 | HSP90B1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA088395 | HSP90B1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
HSP90B1 Proteins
HSP90B1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP010814HU CSB-EP010814HU CSB-BP010814HU CSB-MP010814HU CSB-EP010814HU-B |
Recombinant Human Endoplasmin (HSP90B1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP010814HU1 | Recombinant Human Endoplasmin (HSP90B1), partial | E.coli |
HSP90B1 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP010814DO CSB-EP010814DO CSB-BP010814DO CSB-MP010814DO CSB-EP010814DO-B |
Recombinant Dog Endoplasmin (HSP90B1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HSP90B1 Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP010814CH CSB-EP010814CH CSB-BP010814CH CSB-MP010814CH CSB-EP010814CH-B |
Recombinant Chicken Endoplasmin (HSP90B1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HSP90B1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP010814MO CSB-EP010814MO CSB-BP010814MO CSB-MP010814MO CSB-EP010814MO-B |
Recombinant Mouse Endoplasmin (Hsp90b1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HSP90B1 Proteins for Oryctolagus cuniculus (Rabbit)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP010814RB CSB-EP010814RB CSB-BP010814RB CSB-MP010814RB CSB-EP010814RB-B |
Recombinant Rabbit Endoplasmin (HSP90B1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HSP90B1 Proteins for Mesocricetus auratus (Golden hamster)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP010814MRG CSB-EP010814MRG CSB-BP010814MRG CSB-MP010814MRG CSB-EP010814MRG-B |
Recombinant Mesocricetus auratus Endoplasmin (HSP90B1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HSP90B1 Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP641820PI CSB-EP641820PI CSB-BP641820PI CSB-MP641820PI CSB-EP641820PI-B |
Recombinant Pig Endoplasmin (HSP90B1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HSP90B1 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP703101MOV CSB-EP703101MOV CSB-BP703101MOV CSB-MP703101MOV CSB-EP703101MOV-B |
Recombinant Macaca fascicularis Endoplasmin (HSP90B1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HSP90B1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP714884RA CSB-EP714884RA CSB-BP714884RA CSB-MP714884RA CSB-EP714884RA-B |
Recombinant Rat Endoplasmin (Hsp90b1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HSP90B1 Proteins for Pongo abelii (Sumatran orangutan)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP716064PYX CSB-EP716064PYX CSB-BP716064PYX CSB-MP716064PYX CSB-EP716064PYX-B |
Recombinant Pongo abelii Endoplasmin (HSP90B1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HSP90B1 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP839213BO CSB-EP839213BO CSB-BP839213BO CSB-MP839213BO CSB-EP839213BO-B |
Recombinant Bovine Endoplasmin (HSP90B1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HSP90B1 ELISA Kit
HSP90B1 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E08551h | Human Heat Shock Protein glycoprotein 96,HSP gp96 ELISA Kit | serum, plasma, tissue homogenates | 0.156 ng/mL |
