HSPA1B

HSPA1B，全稱為熱休克蛋白家族A (Hsp70) 成員1B，是一種重要的分子伴侶，在細(xì)胞應(yīng)激反應(yīng)中發(fā)揮關(guān)鍵作用。它與其他熱休克蛋白結(jié)合，幫助穩(wěn)定現(xiàn)有蛋白，防止聚集，并促進(jìn)新合成蛋白質(zhì)的正確折疊。HSPA1B常見別名包括Hsp70-1B、HSP70-2等。該蛋白參與多種細(xì)胞過程，包括抵御應(yīng)激、促進(jìn)蛋白質(zhì)折疊和運(yùn)輸、激活蛋白水解以及調(diào)節(jié)蛋白質(zhì)復(fù)合物的組裝。在疾病方面，HSPA1B與多種疾病相關(guān)，如前列腺疾病、多基因突變、急性高原病、男性不育、青光眼等。研究表明，HSPA1B基因多態(tài)性與肺癌發(fā)病風(fēng)險(xiǎn)和預(yù)后相關(guān)。在藥物研發(fā)領(lǐng)域，HSPA1B已成為抗癌治療的重要靶點(diǎn)之一，相關(guān)藥物正在研發(fā)中，旨在通過調(diào)節(jié)HSPA1B的表達(dá)和活性，抑制腫瘤細(xì)胞的生長和轉(zhuǎn)移。

熱銷產(chǎn)品

HSPA1B Antibody (CSB-PA28047A0Rb)

驗(yàn)證數(shù)據(jù)

Western Blot
Positive WB detected in: Hela whole cell lysate, A549 whole cell lysate, HepG2 whole cell lysate, Jurkat whole cell lysate, MCF-7 whole cell lysate, PC3 whole cell lysate, K562 whole cell lysate
All lanes: HSPA1B antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 71 kDa
Observed band size: 71 kDa

Immunofluorescence staining of PC3 cells with CSB-PA28047A0Rb at 1:106, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Human Heat Shock Protein 70,HSP-70 ELISA Kit (CSB-E08297h)

驗(yàn)證數(shù)據(jù)

貨號：CSB-E08297h

規(guī)格：96T/48T

靈敏度：0.39 ng/mL

檢測范圍：1.56 ng/mL-100 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

HSPA1B Antibody

HSPA1B ELISA Kit

HSPA1B Antibodies

HSPA1B for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA28047A0Rb	HSPA1B Antibody	Human	ELISA, WB, IF
CSB-PA28047B0Rb	HSPA1B Antibody, HRP conjugated	Human	ELISA
CSB-PA28047C0Rb	HSPA1B Antibody, FITC conjugated	Human
CSB-PA28047D0Rb	HSPA1B Antibody, Biotin conjugated	Human	ELISA