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HSPA1L

HSPA1L,全稱為熱休克蛋白家族A (Hsp70) 成員1 樣,是一種在人體內(nèi)由染色體6上的HSPA1L基因編碼的蛋白質(zhì)。該蛋白與HSPA1A和HSPA1B具有高度的同源性,但它們在調(diào)節(jié)功能上存在差異,且不具備可熱誘導(dǎo)的特性。HSPA1L蛋白在細(xì)胞內(nèi)發(fā)揮著重要的分子伴侶作用,它能夠穩(wěn)定其他蛋白質(zhì)的結(jié)構(gòu),防止其聚集,并促進(jìn)新合成的蛋白質(zhì)在細(xì)胞質(zhì)溶膠和細(xì)胞器中的正確折疊。這種功能對于維持細(xì)胞的正常生理活動至關(guān)重要,尤其是在細(xì)胞受到壓力或損傷時。研究表明,HSPA1L蛋白的表達(dá)水平在多種疾病中發(fā)生改變,包括癌癥、神經(jīng)退行性疾病和感染性疾病。因此,HSPA1L蛋白成為了疾病診斷和治療的重要靶點(diǎn)。目前,針對HSPA1L蛋白的藥物研發(fā)主要集中在癌癥治療領(lǐng)域,例如,開發(fā)能夠特異性結(jié)合HSPA1L蛋白的小分子抑制劑或抗體,以抑制其功能或調(diào)節(jié)其表達(dá)水平,從而達(dá)到抑制腫瘤生長或增強(qiáng)腫瘤免疫反應(yīng)的目的。此外,HSPA1L蛋白也被研究用于其他疾病的治療,例如,神經(jīng)退行性疾病和感染性疾病。

熱銷產(chǎn)品

HSPA1L Antibody (CSB-PA010823HA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA010823HA01HU

Western Blot
Positive WB detected in: HepG2 whole cell lysate, Jurkat whole cell lysate, L02 whole cell lysate, 293 whole cell lysate, Raji whole cell lysate
All lanes: HSPA1L antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 71 kDa
Observed band size: 71 kDa

CSB-PA010823HA01HU

IHC image of CSB-PA010823HA01HU diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA010823HA01HU

Immunofluorescence staining of HepG2 cells with CSB-PA010823HA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

HSPA1L Antibodies

HSPA1L for Homo sapiens (Human)

HSPA1L Proteins

HSPA1L Proteins for Bos taurus (Bovine)

HSPA1L Proteins for Mus musculus (Mouse)

HSPA1L Proteins for Homo sapiens (Human)

HSPA1L Proteins for Rattus norvegicus (Rat)

HSPA1L Proteins for Sus scrofa (Pig)

HSPA1L Proteins for Mesocricetus auratus (Golden hamster)

HSPA1L Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)