IFIH1
IFIH1，全名為干擾素誘導(dǎo)的解旋酶C結(jié)構(gòu)域1蛋白，常見別名為MDA5。該蛋白是細(xì)胞內(nèi)病毒RNA傳感器，能夠識(shí)別病毒RNA并觸發(fā)先天免疫反應(yīng)。IFIH1蛋白通過感應(yīng)RNA的長度和二級(jí)結(jié)構(gòu)，將dsRNA寡核苷酸與修飾的RNA結(jié)合，進(jìn)而激活下游的免疫應(yīng)答。IFIH1蛋白與多種疾病相關(guān)，包括Aicardi-Goutières綜合征（AGS）、皮肌炎和間質(zhì)性肺病等。在這些疾病中，IFIH1蛋白的異常表達(dá)或功能缺失會(huì)導(dǎo)致免疫系統(tǒng)的過度激活或抑制，從而引發(fā)炎癥反應(yīng)和組織損傷。針對(duì)IFIH1蛋白的藥物研發(fā)取得了一定的進(jìn)展。例如，JAK抑制劑可以抑制IFIH1蛋白下游的信號(hào)通路，從而減輕炎癥反應(yīng)。此外，抗IFIH1抗體也被用于治療IFIH1相關(guān)疾病，通過阻斷IFIH1蛋白與RNA的結(jié)合，減少免疫應(yīng)答的發(fā)生。這些藥物的研發(fā)為IFIH1相關(guān)疾病的治療提供了新的思路和方法。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP880143HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) IFIH1.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP880143HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) IFIH1.
IFIH1 Recombinant Monoclonal Antibody (CSB-RA963423A0HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: THP-1 whole cell lysate, Mouse lung tissue
All lanes: MDA5 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 117, 26 kDa
Observed band size: 117 kDa
IFIH1 Antibodies
IFIH1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA011017GA01HU | IFIH1 Antibody | Human | ELISA,WB |
| CSB-PA880143ESR2HU | IFIH1 Antibody | Human | ELISA, IHC |
| CSB-PA255539 | IFIH1 Antibody | Human,Mouse | ELISA,WB |
| CSB-PA003209 | IFIH1 Antibody | Human,Mouse | WB, IHC, ELISA |
| CSB-PA880143LA01HU | IFIH1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA880143LB01HU | IFIH1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA880143LC01HU | IFIH1 Antibody, FITC conjugated | Human | |
| CSB-PA880143LD01HU | IFIH1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA963423A0HU | IFIH1 Recombinant Monoclonal Antibody | Human, Mouse | ELISA, WB |
IFIH1 Proteins
IFIH1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP819199MO CSB-BP819199MO CSB-MP819199MO CSB-EP819199MO-B |
Recombinant Mouse Interferon-induced helicase C domain-containing protein 1 (Ifih1), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP819199MO | Recombinant Mouse Interferon-induced helicase C domain-containing protein 1 (Ifih1), partial | E.coli |
IFIH1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP880143HU CSB-BP880143HU CSB-MP880143HU CSB-EP880143HU-B |
Recombinant Human Interferon-induced helicase C domain-containing protein 1 (IFIH1), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP880143HU | Recombinant Human Interferon-induced helicase C domain-containing protein 1 (IFIH1), partial | E.coli |
| CSB-EP880143HUa2 | Recombinant Human Interferon-induced helicase C domain-containing protein 1 (IFIH1), partial | E.coli |
