IFNB1
干擾素β（Interferon beta）又稱IFN-β，屬于I型干擾素家族，主要由成纖維細(xì)胞和免疫細(xì)胞分泌。該蛋白通過結(jié)合細(xì)胞表面受體，激活下游免疫應(yīng)答，抑制病毒復(fù)制并調(diào)節(jié)炎癥反應(yīng)，在抗感染和自身免疫平衡中發(fā)揮關(guān)鍵作用。其合成藥物已被廣泛應(yīng)用于多發(fā)性硬化癥治療，例如Avonex和Rebif等重組干擾素β制劑，可通過減少中樞神經(jīng)系統(tǒng)炎癥損傷延緩病情進(jìn)展。近年來，針對干擾素β的聚乙二醇化修飾技術(shù)提升了藥物穩(wěn)定性，長效劑型Betaseron等進(jìn)一步改善了患者依從性。研究還發(fā)現(xiàn)，該蛋白在腫瘤免疫微環(huán)境調(diào)控中具有潛在價(jià)值，其與檢查點(diǎn)抑制劑聯(lián)用的臨床試驗(yàn)正在探索中。除神經(jīng)系統(tǒng)疾病外，干擾素β異常表達(dá)與紅斑狼瘡、干燥綜合征等自身免疫病也存在關(guān)聯(lián)，相關(guān)機(jī)制研究為開發(fā)靶向療法提供了新思路。
熱銷產(chǎn)品
Recombinant Human Interferon beta protein (IFNB1) (CSB-EP011048HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
IFNB1 (dazukibart) Recombinant Monoclonal Antibody (CSB-RA011048MA1HU)
驗(yàn)證數(shù)據(jù)
IHC image of CSB-RA011048MA1HU diluted at 1:300 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Human IgG labeled by HRP and visualized using 0.05% DAB.
IFNB1 Antibodies
IFNB1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA06515A0Rb | IFNB1 Antibody | Human | ELISA, IHC |
| CSB-PA06515B0Rb | IFNB1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA06515D0Rb | IFNB1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA011048MA1HU | IFNB1 (dazukibart) Recombinant Monoclonal Antibody | Human | ELISA, IHC |
IFNB1 Proteins
IFNB1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011048RA CSB-EP011048RA CSB-BP011048RA CSB-MP011048RA CSB-EP011048RA-B |
Recombinant Rat Interferon beta (Ifnb1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IFNB1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011048HU CSB-BP011048HU CSB-MP011048HU CSB-EP011048HU-B |
Recombinant Human Interferon beta (IFNB1) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP011048HU | Recombinant Human Interferon beta protein (IFNB1) | E.coli |
| CSB-EP011048HUe1 | Recombinant Human Interferon beta (IFNB1) | E.coli |
IFNB1 Proteins for Equus caballus (Horse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011048HO CSB-EP011048HO CSB-BP011048HO CSB-MP011048HO CSB-EP011048HO-B |
Recombinant Horse Interferon beta (IFNB1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IFNB1 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011048BO CSB-EP011048BO CSB-BP011048BO CSB-MP011048BO CSB-EP011048BO-B |
Recombinant Bovine Interferon beta-1 (IFNB1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IFNB1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011048MO CSB-EP011048MO CSB-BP011048MO CSB-MP011048MO CSB-EP011048MO-B |
Recombinant Mouse Interferon beta (Ifnb1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IFNB1 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011048MOV CSB-EP011048MOV CSB-BP011048MOV CSB-MP011048MOV CSB-EP011048MOV-B |
Recombinant Macaca fascicularis Interferon beta (IFNB1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IFNB1 Proteins for Tachyglossus aculeatus aculeatus (Australian echidna)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP747707TKU CSB-EP747707TKU CSB-BP747707TKU CSB-MP747707TKU CSB-EP747707TKU-B |
Recombinant Tachyglossus aculeatus aculeatus Interferon beta (IFNB1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IFNB1 Proteins for Felis catus (Cat) (Felis silvestris catus)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP863088CA CSB-EP863088CA CSB-BP863088CA CSB-MP863088CA CSB-EP863088CA-B |
Recombinant Cat Interferon beta (IFNB1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IFNB1 ELISA Kit
IFNB1 ELISA Kit for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E13699B | Bovine Interferon β,IFN-β/IFNB ELISA Kit |
IFNB1 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E09889h | Human Interferon β,IFN-β/IFNB ELISA Kit | serum, urine, cell culture supernates, tissue homogenates, cerebrospinal fluid (CSF) | 7.8 pg/mL |
IFNB1 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04945m | Mouse Interferon β,IFN-β/IFNB ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates, cell lysates | 3.9 pg/mL |
IFNB1 ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04845r | Rat Interferon β,IFN-β/IFNB ELISA Kit | serum, plasma, tissue homogenates | 3.9 pg/mL |
IFNB1 ELISA Kit for Monkey
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E17829Mk | Monkey Interferon β(IFN-β)ELISA Kit | serum, plasma | 7.8 pg/mL |
