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IKZF1

IKZF1,即IKAROS家族鋅指蛋白1,別名IK1、LYF1、hIk-1、IKAROS、PPP1R92、PRO0758、ZNFN1A1。IKZF1屬于IKAROS家族轉(zhuǎn)錄因子,具有多個(gè)鋅指結(jié)構(gòu)域,參與染色質(zhì)重塑和淋巴細(xì)胞分化的調(diào)控。IKZF1與DNA結(jié)合以及與其他核蛋白的相互作用,能夠作為轉(zhuǎn)錄激活因子或抑制因子,調(diào)節(jié)靶基因的表達(dá)。IKZF1在多種造血和免疫細(xì)胞的發(fā)育中發(fā)揮重要作用,尤其是在B細(xì)胞和T細(xì)胞的分化、增殖中起關(guān)鍵作用。IKZF1的功能紊亂與多種疾病相關(guān),包括惡性腫瘤、自身免疫病和免疫缺陷等,其缺失或功能失調(diào)與急性淋巴細(xì)胞白血?。ˋLL)和急性髓系白血病有關(guān)。

熱銷產(chǎn)品

Recombinant Human DNA-binding protein Ikaros (IKZF1) (CSB-EP621668HU)

驗(yàn)證數(shù)據(jù)

CSB-EP621668HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP621668HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) IKZF1.

CSB-EP621668HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP621668HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) IKZF1.

IKZF1 Recombinant Monoclonal Antibody (CSB-RA266291A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA266291A0HU

Overlay Peak curve showing Jurkat cells stained with CSB-RA266291A0HU (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

IKZF1 Antibodies

IKZF1 for Homo sapiens (Human)

IKZF1 Proteins

IKZF1 Proteins for Mus musculus (Mouse)

IKZF1 Proteins for Gallus gallus (Chicken)

IKZF1 Proteins for Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)

IKZF1 Proteins for Homo sapiens (Human)