IL31RA

白細(xì)胞介素31受體α（IL31RA），又稱IL-31Rα或CRL3，是介導(dǎo)細(xì)胞因子IL-31功能的核心蛋白。它與輔助亞基OSMRβ結(jié)合形成完整受體復(fù)合物，主要分布于皮膚感覺神經(jīng)元和免疫細(xì)胞表面。當(dāng)IL-31與其結(jié)合時(shí)，會(huì)觸發(fā)強(qiáng)烈的瘙癢感知并促進(jìn)炎癥介質(zhì)釋放，這一現(xiàn)象在特應(yīng)性皮炎患者的病灶皮膚中尤為顯著，其過度激活可導(dǎo)致慢性瘙癢和表皮屏障損傷。IL31RA在結(jié)節(jié)性癢疹、慢性蕁麻疹等疾病中異常高表達(dá)，并與神經(jīng)免疫交互失調(diào)密切相關(guān)。基于此靶點(diǎn)開發(fā)的單抗藥物nemolizumab已取得突破，全球多中心試驗(yàn)顯示其能快速緩解頑固性瘙癢，降低患者抓撓頻率，2022年在日本獲批用于特應(yīng)性皮炎治療。目前該藥物正拓展至慢性腎病相關(guān)性瘙癢等新適應(yīng)癥，為IL-31信號(hào)異常相關(guān)疾病提供了精準(zhǔn)干預(yù)策略。

熱銷產(chǎn)品

IL31RA Antibody (CSB-PA854162ESR2HU)

驗(yàn)證數(shù)據(jù)

Western blot
All lanes: IL31RA antibody at 1.45μg/ml + Mouse kidney tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 83, 87, 75, 42, 78, 71, 59, 67, 64, 70, 85 kDa
Observed band size: 83 kDa

Human Interleukin-31 receptor subunit alpha(IL31RA) ELISA kit (CSB-EL011654HU)

驗(yàn)證數(shù)據(jù)

貨號(hào)：CSB-EL011654HU

規(guī)格：96T/48T

靈敏度：1.56 pg/mL

檢測(cè)范圍：6.25 pg/mL-400 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

IL31RA Antibody

IL31RA Protein

IL31RA ELISA Kit

IL31RA Antibodies

IL31RA for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA004737	IL31RA Antibody	Human	WB, ELISA
CSB-PA796040	IL31RA Antibody	Human	ELISA,IHC
CSB-PA107902	IL31RA Antibody	Human	ELISA,IHC
CSB-PA125161	IL31RA Antibody	Human	ELISA,WB,IHC
CSB-PA854162ESR1HU	IL31RA Antibody	Human	ELISA, IHC
CSB-PA854162ESR2HU	IL31RA Antibody	Human, Mouse	ELISA, WB

IL31RA Proteins

IL31RA Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP854162HU CSB-EP854162HU CSB-BP854162HU CSB-MP854162HU CSB-EP854162HU-B	Recombinant Human Interleukin-31 receptor subunit alpha (IL31RA), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli