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IRAK4

IRAK4,即白細胞介素-1受體相關激酶4,別名IL-1受體相關激酶4。它是一種在Toll樣受體(TLRs)和IL-1受體介導的炎癥發(fā)生中的關鍵性蛋白。IRAK4由人體細胞自身的基因編碼,其作用機制主要是通過參與Toll樣受體信號通路,激活下游的NF-κB和AP-1轉錄因子,從而誘導炎癥因子、細胞因子、趨化因子的表達 。IRAK4在生物學上的意義非常重要,它不僅參與了炎癥反應的正向調(diào)節(jié),還廣泛參與了細胞內(nèi)反應的網(wǎng)絡性調(diào)節(jié)。IRAK4的功能異常與多種炎癥性疾病的發(fā)生發(fā)展有關,包括類風濕性關節(jié)炎、特應性皮炎、化膿性汗腺炎等。此外,IRAK4的過表達可以增強LPS誘導的NADPH氧化酶活性,誘導下游的p38 MAPK的信號轉導,進一步擴展了IRAK4的生物學功能 。因此,IRAK4是抗炎癥和腫瘤研究中的一個重要靶點,針對IRAK4的小分子抑制劑和蛋白降解劑正在被開發(fā)用于治療相關疾病。

熱銷產(chǎn)品

IRAK4 Recombinant Monoclonal Antibody (CSB-RA284992A0HU)

驗證數(shù)據(jù)

CSB-RA284992A0HU

Western Blot
Positive WB detected in: THP-1 whole cell lysate, U251 whole cell lysate
All lanes: IRAK4 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 52, 38 kDa
Observed band size: 55 kDa

CSB-RA284992A0HU

Overlay histogram showing Jurkat cells stained with CSB-RA284992A0HU (red line) at 1:50. The cells were fixed with 70% Ethylalcohol (18h) and then incubated in 10% normal goat serum to block non-specific protein-protein interactions followedby the antibody (1μg/1*106 cells) for 1 h at 4℃.The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 30min at 4℃. Control antibody (green line) was Rabbit IgG (1μg/1*106 cells) used under the same conditions. Acquisition of >10,000 events was performed.

IRAK4 Antibody (CSB-PA011812ESR1HU)

驗證數(shù)據(jù)

CSB-PA011812ESR1HU

Western blot
All lanes: Interleukin-1 receptor-associated kinase 4 antibody at 4μg/ml + Jurkat whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 52, 38 kDa
Observed band size: 52 kDa

CSB-PA011812ESR1HU

Immunoprecipitating IRAK4 in MCF-7 whole cell lysate
Lane 1: Rabbit control IgG instead of CSB-PA011812ESR1HU in MCF-7 whole cell lysate. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
Lane 2: CSB-PA011812ESR1HU (8μg) + MCF-7 whole cell lysate (500μg)
Lane 3: MCF-7 whole cell lysate (10μg)

IRAK4 Antibodies

IRAK4 for Homo sapiens (Human)

IRAK4 Proteins

IRAK4 Proteins for Mus musculus (Mouse)

IRAK4 Proteins for Homo sapiens (Human)

IRAK4 Proteins for Bos taurus (Bovine)

IRAK4 ELISA Kit

IRAK4 ELISA Kit for Homo sapiens (Human)