ITGAM
ITGAM，全稱為整合素αM鏈，是一種重要的細(xì)胞表面受體，參與多種細(xì)胞間相互作用和信號(hào)傳導(dǎo)過程。它常見別名包括MAC-1和CD11b，在免疫細(xì)胞，如巨噬細(xì)胞、中性粒細(xì)胞和NK細(xì)胞中高度表達(dá)。ITGAM與β2鏈（ITGB2）結(jié)合形成αMβ2整合素（Mac-1），能夠識(shí)別并結(jié)合多種配體，包括ICAM-1、C3bi、纖維蛋白原和纖維連接蛋白等。這種受體在細(xì)胞粘附、遷移、吞噬和信號(hào)傳導(dǎo)中發(fā)揮著關(guān)鍵作用。
Mac-1參與多種生理和病理過程，如免疫應(yīng)答、炎癥反應(yīng)和傷口愈合。它還在腫瘤細(xì)胞的增殖、轉(zhuǎn)移和耐藥性中發(fā)揮作用。因此，Mac-1成為免疫治療和抗腫瘤藥物研發(fā)的重要靶點(diǎn)。目前，針對(duì)Mac-1的藥物研發(fā)主要集中在抗體藥物和免疫檢查點(diǎn)抑制劑等方面。例如，抗Mac-1抗體可用于靶向清除巨噬細(xì)胞，從而抑制腫瘤生長(zhǎng)和轉(zhuǎn)移；免疫檢查點(diǎn)抑制劑可與Mac-1結(jié)合，阻斷其與配體的結(jié)合，從而抑制腫瘤細(xì)胞的免疫逃逸。
熱銷產(chǎn)品
Recombinant Human Integrin alpha-M (ITGAM), partial (CSB-EP011876HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
ITGAM Recombinant Monoclonal Antibody (CSB-RA067983A0HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in:A549 whole cell lysate(30μg)
All lanes: CD11b antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/40000 dilution
Predicted band size: 127 kDa
Observed band size: 127 kDa
Exposure time：3min
Human Integrin αM,ITG/CD11b ELISA Kit (CSB-E11638h)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-E11638h
規(guī)格：96T/48T
靈敏度：0.195 ng/mL
檢測(cè)范圍：0.78 ng/mL-50 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
ITGAM Antibodies
ITGAM for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA148981 | ITGAM Antibody | Human | ELISA,IHC |
| CSB-PA073350 | ITGAM Antibody | Human | ELISA,IHC |
| CSB-PA011876LA01HU | ITGAM Antibody | Human | ELISA, IHC, IF |
| CSB-PA011876LB01HU | ITGAM Antibody, HRP conjugated | Human | ELISA |
| CSB-PA011876LC01HU | ITGAM Antibody, FITC conjugated | Human | |
| CSB-PA011876LD01HU | ITGAM Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA067983A0HU | ITGAM Recombinant Monoclonal Antibody | Human | ELISA, WB |
ITGAM Proteins
ITGAM Proteins for Cavia porcellus (Guinea pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011876GU CSB-EP011876GU CSB-BP011876GU CSB-MP011876GU CSB-EP011876GU-B |
Recombinant Guinea pig Integrin alpha-M (ITGAM) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ITGAM Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011876HU CSB-BP011876HU CSB-MP011876HU CSB-EP011876HU-B |
Recombinant Human Integrin alpha-M (ITGAM), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP011876HU | Recombinant Human Integrin alpha-M (ITGAM), partial | E.coli |
ITGAM Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011876MO CSB-EP011876MO CSB-BP011876MO CSB-MP011876MO CSB-EP011876MO-B |
Recombinant Mouse Integrin alpha-M (Itgam), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ITGAM ELISA Kit
ITGAM ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E11638h | Human Integrin αM,ITG/CD11b ELISA Kit | serum, plasma, tissue homogenates | 0.195 ng/mL |
ITGAM ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E17417m | Mouse Integrin alpha-M (Itgam/CD11b) ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates | 3.9 pg/mL |
