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ITGAV

整合素αV(ITGAV),也稱為CD51或VTNR,是一類廣泛分布于細(xì)胞表面的跨膜受體蛋白,通過與β亞基結(jié)合形成異二聚體,參與調(diào)控細(xì)胞與細(xì)胞外基質(zhì)的相互作用。該蛋白在胚胎發(fā)育、組織修復(fù)及免疫調(diào)節(jié)等生理過程中發(fā)揮關(guān)鍵作用,尤其在腫瘤侵襲轉(zhuǎn)移、血管生成和纖維化疾病中備受關(guān)注。研究表明,ITGAV異常表達(dá)與多種惡性腫瘤(如膠質(zhì)母細(xì)胞瘤、乳腺癌)、器官纖維化(肺、肝)及骨代謝疾病密切相關(guān),其功能失調(diào)可導(dǎo)致細(xì)胞黏附異常和微環(huán)境重塑。
近年來,靶向ITGAV的藥物研發(fā)進(jìn)展顯著。例如,抑制劑Cilengitide通過阻斷αVβ3和αVβ5整合素活性,曾進(jìn)入晚期膠質(zhì)瘤的III期臨床試驗(yàn),但因療效未達(dá)預(yù)期而終止。當(dāng)前研究聚焦于開發(fā)新型小分子拮抗劑和抗體藥物,探索其在抗腫瘤血管生成、抑制轉(zhuǎn)移及纖維化治療中的潛力。此外,ITGAV與免疫檢查點(diǎn)分子的協(xié)同作用也為聯(lián)合療法提供了新方向,部分候選藥物已進(jìn)入早期臨床評(píng)估階段。

熱銷產(chǎn)品

Recombinant Human Integrin alpha-V&Integrin beta-6 (ITGAV&ITGB6), partial (Active) (CSB-MP6145HU)

驗(yàn)證數(shù)據(jù)

CSB-MP6145HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP6145HU

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human ITGAV&ITGB6 at 2 μg/ml can bind Human TGFB1 (CSB-MP023446HU(A4)c9). The EC50 is 8.576-10.18 ng/mL.

CSB-MP6145HU

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human ITGAV&ITGB6 at 2 μg/ml can bind Anti-ITGB6 recombinant antibody (CSB-RA011890MA1HU). The EC50 is 7.021-9.054 ng/mL.

CSB-MP6145HU

The purity of ITGAV&ITGB6 was greater than 90% as determined by SEC-HPLC

ITGAV Recombinant Monoclonal Antibody (CSB-RA279866A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA279866A0HU

Western Blot
Positive WB detected in: U-251 whole cell lysate, Hela whole cell lysate, HepG2 whole cell lysate
All lanes: ITGAV antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 117, 113, 112 kDa
Observed band size: 130 kDa

CSB-RA279866A0HU

IHC image of CSB-RA279866A0HU diluted at 1:100 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

ITGAV Antibodies

ITGAV for Homo sapiens (Human)

ITGAV Proteins

ITGAV Proteins for Bos taurus (Bovine)

ITGAV Proteins for Mus musculus (Mouse)

ITGAV Proteins for Gallus gallus (Chicken)

ITGAV Proteins for Homo sapiens (Human)