ITGAX
ITGAX，全稱為整合素αX鏈蛋白，常見別名包括CD11c和補(bǔ)體成分3受體4亞基。該蛋白是白細(xì)胞特異性整合素的重要組成部分，與β2鏈（ITGB2）結(jié)合形成復(fù)合物，參與細(xì)胞粘附、遷移和信號(hào)傳導(dǎo)等過(guò)程。ITGAX蛋白在免疫細(xì)胞中發(fā)揮關(guān)鍵作用，尤其是在樹突狀細(xì)胞、單核細(xì)胞和巨噬細(xì)胞中高表達(dá)。它參與多種免疫反應(yīng)，包括炎癥反應(yīng)、抗原呈遞和免疫調(diào)節(jié)。ITGAX蛋白還與某些疾病的發(fā)生發(fā)展密切相關(guān)，如癌癥、自身免疫性疾病和感染性疾病。在藥物研發(fā)方面，針對(duì)ITGAX蛋白的抗體藥物和抑制劑已被開發(fā)用于治療癌癥和炎癥性疾病。例如，抗ITGAX抗體可用于阻斷腫瘤細(xì)胞的粘附和轉(zhuǎn)移，而ITGAX抑制劑則可減輕炎癥反應(yīng)。目前，ITGAX蛋白相關(guān)的研究仍在不斷深入，未來(lái)有望為更多疾病的治療提供新的策略。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA782639(ITGAX Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA782639(ITGAX Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)
ITGAX Antibody (CSB-PA011879ESR1HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: ITGAXantibody IgG at 1.59μg/ml + Mouse kidney tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 128 kDa
Observed band size: 128 kDa
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA011879ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA011879ESR1HU at dilution of 1:100
Immunofluorescent analysis of Hela cells using CSB-PA011879ESR1HU at dilution of 1: 100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
ITGAX Antibodies
ITGAX for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA011879GA01HU | ITGAX Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA091944 | ITGAX Antibody | Human | ELISA,WB |
| CSB-PA843535 | ITGAX Antibody | Human | ELISA,IHC |
| CSB-PA782639 | ITGAX Antibody | Human | ELISA,IHC |
| CSB-PA011879ESR1HU | ITGAX Antibody | Human, Mouse | ELISA, WB, IHC, IF |
ITGAX Proteins
ITGAX Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP011879HU CSB-EP011879HU CSB-BP011879HU CSB-MP011879HU CSB-EP011879HU-B |
Recombinant Human Integrin alpha-X (ITGAX), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ITGAX Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP874106MO CSB-EP874106MO CSB-BP874106MO CSB-MP874106MO CSB-EP874106MO-B |
Recombinant Mouse Integrin alpha-X (Itgax), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-BP874106MO1 | Recombinant Mouse Integrin alpha-X (Itgax), partial | Baculovirus |
