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ITGB1

整合素β1(Integrin β1,又稱CD29)是整合素家族的重要成員,常與不同α亞基結(jié)合形成跨膜受體,例如與α4形成VLA-4、與α5形成纖維連接蛋白受體。這類復(fù)合物通過(guò)識(shí)別細(xì)胞外基質(zhì)中的層粘連蛋白、膠原等成分,參與細(xì)胞黏附、遷移和微環(huán)境感知,ITGB1功能異常常導(dǎo)致細(xì)胞極性喪失和異常增殖。在病理層面,ITGB1在乳腺癌、胃癌等實(shí)體瘤中過(guò)度激活,通過(guò)調(diào)控上皮間質(zhì)轉(zhuǎn)化過(guò)程促進(jìn)腫瘤侵襲;其異常表達(dá)還與特發(fā)性肺纖維化、肝硬化等器官纖維化進(jìn)程密切相關(guān)。目前針對(duì)該靶點(diǎn)的藥物開(kāi)發(fā)聚焦于抗腫瘤領(lǐng)域,例如抗體藥物偶聯(lián)物(ADC)LXY30通過(guò)特異性阻斷整合素β1抑制三陰性乳腺癌轉(zhuǎn)移,已進(jìn)入Ⅰ期臨床試驗(yàn)。小分子抑制劑ATN-161在動(dòng)物實(shí)驗(yàn)中顯示出阻斷腫瘤血管生成潛力,但其臨床轉(zhuǎn)化仍受限于組織選擇性不足的挑戰(zhàn)。

熱銷產(chǎn)品

ITGB1 Recombinant Monoclonal Antibody (CSB-RA011880A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA011880A0HU

Western Blot
Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, SH-SY5Y whole cell lysate, U251 whole cell lysate
All lanes: Integrin beta-1/CD29 antibody at 1.9μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 89, 88, 92 KDa
Observed band size: 130 KDa

CSB-RA011880A0HU

IHC image of CSB-RA011880A0HU diluted at 1:185 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-RA011880A0HU

Immunofluorescence staining of Hela cells with CSB-RA011880A0HU at 1:61, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).

CSB-RA011880A0HU

Overlay histogram showing MCF-7 cells stained with CSB-RA011880A0HU (red line) at 1:50. The cells were fixed with 70% Ethylalcohol (18h) and then permeabilized with 0.3% Triton X-100 for 2 min. The cells were then incubated in 1x PBS /10% normal goat serum to block non-specific protein-protein interactions followed by primary antibody for 1 h at 4℃. The secondary antibody used was FITC goat anti-rabbit IgG (H+L) at 1/200 dilution for 1 h at 4℃. Control antibody (green line) was used under the same conditions. Acquisition of >10,000 events was performed.

Human Integrin beta-1(ITGB1) ELISA kit (CSB-EL011880HU)

驗(yàn)證數(shù)據(jù)

CSB-EL011880HU 標(biāo)準(zhǔn)曲線

貨號(hào):CSB-EL011880HU

規(guī)格:96T/48T

靈敏度:15.6 pg/mL

檢測(cè)范圍:62.5 pg/mL-4000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

ITGB1 Antibodies

ITGB1 for Rattus norvegicus (Rat)

ITGB1 for Homo sapiens (Human)

ITGB1 for Mus musculus (Mouse)

ITGB1 Proteins

ITGB1 Proteins for Rattus norvegicus (Rat)

ITGB1 Proteins for Felis catus (Cat) (Felis silvestris catus)

ITGB1 Proteins for Bos taurus (Bovine)

ITGB1 Proteins for Homo sapiens (Human)

ITGB1 Proteins for Gallus gallus (Chicken)

ITGB1 Proteins for Mus musculus (Mouse)

ITGB1 Proteins for Ovis aries (Sheep)

ITGB1 Proteins for Camelus bactrianus (Bactrian camel)

ITGB1 Proteins for Pongo abelii (Sumatran orangutan)

ITGB1 Proteins for Sus scrofa (Pig)

ITGB1 ELISA Kit

ITGB1 ELISA Kit for Homo sapiens (Human)