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JAK3

JAK3,即Janus激酶3,別名Janus Kinase3、L-JAK,是JAK激酶家族中的一個關(guān)鍵成員,主要在免疫系統(tǒng)的細(xì)胞中發(fā)揮作用。作為一種非受體型酪氨酸激酶,JAK3通過參與JAK-STAT信號通路,調(diào)控細(xì)胞因子介導(dǎo)的細(xì)胞增殖、分化和凋亡等過程。JAK3的活性對維持免疫平衡至關(guān)重要,其異常表達(dá)或功能失調(diào)與多種自身免疫性疾病,如類風(fēng)濕性關(guān)節(jié)炎、系統(tǒng)性紅斑狼瘡等有關(guān)。此外,JAK3也是癌癥治療中的潛在靶點(diǎn),針對JAK3的抑制劑,如托法替布,已被批準(zhǔn)用于治療某些自身免疫性疾病,展現(xiàn)出良好的療效和安全性。因此,JAK3在藥物開發(fā)和疾病治療中具有重要的生物學(xué)意義和臨床應(yīng)用價值。

熱銷產(chǎn)品

JAK3 Recombinant Monoclonal Antibody (CSB-RA206737A0HU)

驗證數(shù)據(jù)

CSB-RA206737A0HU

IHC image of CSB-RA206737A0HU diluted at 1:100 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

JAK3 Antibodies

JAK3 for Homo sapiens (Human)

JAK3 Proteins

JAK3 Proteins for Homo sapiens (Human)

JAK3 Proteins for Mus musculus (Mouse)

JAK3 Proteins for Rattus norvegicus (Rat)