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KCNMB1

Calcium-activated potassium channel subunit beta-1 is a protein in humans that is encoded by KCNMB1 gene. Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.

KCNMB1 Antibodies

KCNMB1 for Homo sapiens (Human)

KCNMB1 Proteins

KCNMB1 Proteins for Oryctolagus cuniculus (Rabbit)

KCNMB1 Proteins for Rattus norvegicus (Rat)

KCNMB1 Proteins for Homo sapiens (Human)

KCNMB1 Proteins for Bos taurus (Bovine)

KCNMB1 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

KCNMB1 Proteins for Mus musculus (Mouse)

KCNMB1 Proteins for Coturnix coturnix japonica (Japanese quail) (Coturnix japonica)