KCNQ3
KCNQ3,即鉀電壓門控通道亞家族Q成員3,別名Kv7.3、KCNQ2-like protein、KCNQ3 potassium channel等。KCNQ3基因位于人類3號(hào)染色體上,編碼的蛋白質(zhì)屬于電壓門控鉀離子通道家族成員。KCNQ3的作用機(jī)制是通過(guò)形成鉀離子通道,調(diào)節(jié)鉀離子的流動(dòng),從而控制細(xì)胞膜電位,維持神經(jīng)元的興奮性。在神經(jīng)系統(tǒng)中,KCNQ3與KCNQ2或KCNQ5等亞單位形成異源四聚體,構(gòu)成M型鉀通道,參與調(diào)節(jié)神經(jīng)元的靜息膜電位和動(dòng)作電位的復(fù)極化過(guò)程。KCNQ3功能異常與多種神經(jīng)系統(tǒng)疾病相關(guān),如癲癇、神經(jīng)性疼痛等。此外,KCNQ3的表達(dá)和功能也與腫瘤的發(fā)生發(fā)展有關(guān),是研究和治療相關(guān)疾病的潛在靶點(diǎn)。
熱銷產(chǎn)品
KCNQ3 Antibody (CSB-PA012091LA01HU)
驗(yàn)證數(shù)據(jù)

Western Blot
Positive WB detected in: K562 whole cell lysate(30μg), THP-1 whole cell lysate(30μg), JK whole cell lysate(30μg), HepG2 whole cell lysate(30μg), A549 whole cell lysate(30μg), Mouse Brain tissue lysate(30μg),Rat Brain tissue lysate(30μg)
All lanes: KCNQ3 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/20000 dilution
Predicted band size: 97,85,90,100 kDa
Observed band size: 100 kDa
Exposure time:120s

Immunofluorescence staining of HepG2 cell with CSB-PA012091LA01HU at 1:10, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Immunofluorescence staining of HepG2 cell with 5% goat serum, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Immunofluorescence staining of SH-SY5Y cell with CSB-PA012091LA01HU at 1:10, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Immunofluorescence staining of SH-SY5Y cell with 5% goat serum, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
KCNQ3 Antibodies
KCNQ3 for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
---|---|---|---|
CSB-PA012091LA01HU | KCNQ3 Antibody | Human | ELISA, WB, IF |
CSB-PA012091LB01HU | KCNQ3 Antibody, HRP conjugated | Human | ELISA |
CSB-PA012091LC01HU | KCNQ3 Antibody, FITC conjugated | Human | |
CSB-PA012091LD01HU | KCNQ3 Antibody, Biotin conjugated | Human | ELISA |
KCNQ3 Proteins
KCNQ3 Proteins for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
---|---|---|
CSB-YP012091HU CSB-EP012091HU CSB-BP012091HU CSB-MP012091HU CSB-EP012091HU-B |
Recombinant Human Potassium voltage-gated channel subfamily KQT member 3 (KCNQ3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |