KEAP1

KEAP1，即Kelch樣ECH相關(guān)蛋白1，別名IKBKE抑制因子、Kelch-like protein 19等。它是一種由KEAP1基因編碼的蛋白質(zhì)，主要在細(xì)胞質(zhì)中發(fā)揮作用。KEAP1的作用機(jī)制主要是通過與NRF2蛋白相互作用，促進(jìn)NRF2的泛素化和蛋白酶體降解，從而抑制NRF2介導(dǎo)的抗氧化應(yīng)激和代謝調(diào)控基因的表達(dá)。KEAP1的功能異常與多種疾病有關(guān)，尤其是癌癥，其中KEAP1的突變或異常表達(dá)可能導(dǎo)致NRF2信號(hào)通路的異常激活，進(jìn)而影響腫瘤細(xì)胞的代謝和生存。因此，KEAP1-NRF2信號(hào)通路是癌癥治療中的一個(gè)潛在靶點(diǎn)。

熱銷產(chǎn)品

Recombinant Human Kelch-like ECH-associated protein 1 (KEAP1) (CSB-EP012147HU)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

KEAP1 Antibody (CSB-PA012147LA01HU)

驗(yàn)證數(shù)據(jù)

Western blot
All lanes: KEAP1 antibody at 2µg/ml
Lane 1: Mouse kidney tissue
Lane 2: NIH/3T3 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 70 kDa
Observed band size: 70 kDa

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA012147LA01HU at dilution of 1:100

Human Kelch-like ECH-associated protein 1(KEAP1) ELISA kit (CSB-EL012147HU)

驗(yàn)證數(shù)據(jù)

貨號(hào)：CSB-EL012147HU

規(guī)格：96T/48T

靈敏度：6.25 pg/mL

檢測范圍：25 pg/mL-1600 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

KEAP1 Antibody

KEAP1 Protein

KEAP1 ELISA Kit

KEAP1 Antibodies

KEAP1 for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA012147GA01HU	KEAP1 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA005148	KEAP1 Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA012147LA01HU	KEAP1 Antibody	Human, Mouse	ELISA, WB, IHC
CSB-PA012147LC01HU	KEAP1 Antibody, FITC conjugated	Human
CSB-PA012147LD01HU	KEAP1 Antibody, Biotin conjugated	Human	ELISA
CSB-PA247380	KEAP1 Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA011976	KEAP1 Antibody	Human,Mouse,Rat	ELISA,IHC

KEAP1 for Mus musculus (Mouse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA012147LA01MO	Keap1 Antibody	Mouse, Human	ELISA, WB
CSB-PA012147LD01MO	Keap1 Antibody, Biotin conjugated	Mouse	ELISA
CSB-PA012147LB01MO	Keap1 Antibody, HRP conjugated	Mouse	ELISA

KEAP1 Proteins

KEAP1 Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP012147RA CSB-EP012147RA CSB-BP012147RA CSB-MP012147RA CSB-EP012147RA-B	Recombinant Rat Kelch-like ECH-associated protein 1 (Keap1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KEAP1 Proteins for Sus scrofa (Pig)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP012147PI CSB-EP012147PI CSB-BP012147PI CSB-MP012147PI CSB-EP012147PI-B	Recombinant Pig Kelch-like ECH-associated protein 1 (KEAP1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KEAP1 Proteins for Pongo abelii (Sumatran orangutan)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP012147PYX CSB-EP012147PYX CSB-BP012147PYX CSB-MP012147PYX CSB-EP012147PYX-B	Recombinant Pongo abelii Kelch-like ECH-associated protein 1 (KEAP1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KEAP1 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP012147MO CSB-BP012147MO CSB-MP012147MO CSB-EP012147MO-B	Recombinant Mouse Kelch-like ECH-associated protein 1 (Keap1)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP012147MO	Recombinant Mouse Kelch-like ECH-associated protein 1 (Keap1)	E.coli

KEAP1 Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP012147HU	Recombinant Human Kelch-like ECH-associated protein 1 (KEAP1)	Yeast
CSB-BP012147HU CSB-MP012147HU	Recombinant Human Kelch-like ECH-associated protein 1 (KEAP1)	Baculovirus Mammalian cell
CSB-EP012147HU	Recombinant Human Kelch-like ECH-associated protein 1 (KEAP1)	E.coli
CSB-EP012147HU1	Recombinant HumanKelch-like ECH-associated protein 1 (KEAP1), partial	E.coli
CSB-EP012147HU-B	Recombinant Human Kelch-like ECH-associated protein 1 (KEAP1), Biotinylated	E.coli