KIF18A，即驅(qū)動(dòng)蛋白家族成員18A。別名CD319。它在細(xì)胞內(nèi)主要位于細(xì)胞質(zhì)和細(xì)胞核中，由898個(gè)氨基酸殘基組成，分子量約為100kDa。KIF18A的作用機(jī)制涉及其作為kinesin-8家族成員，依靠水解ATP釋放的能量，以微管為軌道向正極方向運(yùn)動(dòng)，調(diào)控微管的動(dòng)態(tài)不穩(wěn)定性，發(fā)揮類(lèi)似于微管解聚酶的活性。KIF18A對(duì)維持染色體穩(wěn)定性和控制有絲分裂過(guò)程中的染色體排列至關(guān)重要，其功能異常可能導(dǎo)致細(xì)胞轉(zhuǎn)化和致癌。多項(xiàng)研究表明，KIF18A在多種癌細(xì)胞中具有高表達(dá)，與乳腺癌、透明細(xì)胞腎癌和結(jié)腸癌患者的預(yù)后相關(guān)，參與肝細(xì)胞癌的侵襲和轉(zhuǎn)移，并與細(xì)胞增殖、腫瘤分期和多發(fā)性腫瘤的預(yù)后相關(guān)。KIF18A是一種可能的癌癥預(yù)后生物標(biāo)志物，也是抗有絲分裂治療的潛在靶點(diǎn)。

熱銷(xiāo)產(chǎn)品

KIF18A Antibody (CSB-PA847753LA01HU)

驗(yàn)證數(shù)據(jù)

Immunofluorescence staining of A549 cells with CSB-PA847753LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).