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KLK1

KLK1全稱(chēng)為激肽釋放酶1,又稱(chēng)組織激肽釋放酶或hK1,是絲氨酸蛋白酶家族成員。該蛋白在人體多個(gè)組織表達(dá),能夠水解低分子量激肽原生成活性激肽,參與調(diào)節(jié)血壓、電解質(zhì)平衡及炎癥反應(yīng)過(guò)程。KLK1與緩激肽系統(tǒng)存在密切關(guān)聯(lián),在血管舒張、細(xì)胞增殖等生理活動(dòng)中扮演關(guān)鍵角色。
KLK1異常表達(dá)與高血壓、慢性腎病及動(dòng)脈粥樣硬化等疾病相關(guān),尤其在糖尿病腎病患者的尿液中常檢測(cè)到濃度升高。近年來(lái),基于其調(diào)節(jié)血壓的特性,科研團(tuán)隊(duì)嘗試開(kāi)發(fā)重組激肽釋放酶1作為治療缺血性中風(fēng)和心肌梗死的候選藥物。同時(shí),針對(duì)其抑制劑的研究也在推進(jìn)中,用于緩解激肽過(guò)度釋放引發(fā)的炎癥反應(yīng)。目前已有部分小分子化合物進(jìn)入臨床前研究階段,但成藥性仍需進(jìn)一步驗(yàn)證。

熱銷(xiāo)產(chǎn)品

Recombinant Human Kallikrein-1 (KLK1) (CSB-EP012446HU)

驗(yàn)證數(shù)據(jù)

CSB-EP012446HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

KLK1 Antibody (CSB-PA012446LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA012446LA01HU

IHC image of CSB-PA012446LA01HU diluted at 1:300 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA012446LA01HU

IHC image of CSB-PA012446LA01HU diluted at 1:300 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA012446LA01HU

Immunofluorescence staining of Hela cells with CSB-PA012446LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Human Kallikrein 1,KLK 1 ELISA Kit (CSB-E11437h)

驗(yàn)證數(shù)據(jù)

CSB-E11437h 標(biāo)準(zhǔn)曲線

貨號(hào):CSB-E11437h

規(guī)格:96T/48T

靈敏度:0.195 ng/mL

檢測(cè)范圍:0.78 ng/mL-50 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

KLK1 Antibodies

KLK1 for Homo sapiens (Human)

KLK1 Proteins

KLK1 Proteins for Mus musculus (Mouse)

KLK1 Proteins for Homo sapiens (Human)

KLK1 Proteins for Papio hamadryas (Hamadryas baboon)

KLK1 Proteins for Blarina brevicauda (Short-tailed shrew)

KLK1 ELISA Kit

KLK1 ELISA Kit for Homo sapiens (Human)