KLK3全稱為激肽釋放酶相關(guān)肽酶3，又稱前列腺特異性抗原（PSA），是人體精液中的重要成分。該蛋白由前列腺上皮細(xì)胞分泌，主要功能是通過(guò)分解精囊凝固蛋白促進(jìn)精子液化，在生殖過(guò)程中起關(guān)鍵作用。KLK3表達(dá)受雄激素嚴(yán)格調(diào)控，臨床上常作為前列腺癌篩查的核心生物標(biāo)志物。當(dāng)血清PSA水平異常升高時(shí)，常提示前列腺增生、炎癥或惡性腫瘤可能，但需結(jié)合直腸指檢、影像學(xué)檢查綜合判斷。
PSA可通過(guò)裂解胰島素樣生長(zhǎng)因子結(jié)合蛋白（IGFBP）影響細(xì)胞增殖通路，與腫瘤轉(zhuǎn)移存在潛在關(guān)聯(lián)?；谠摰鞍滋匦蚤_(kāi)發(fā)的診斷試劑已廣泛應(yīng)用于前列腺癌早期檢測(cè)，全球年檢測(cè)量超過(guò)1億人次。治療領(lǐng)域，靶向PSA的放射性核素療法（如177Lu-PSMA）在晚期前列腺癌患者中展現(xiàn)出顯著療效，目前FDA已批準(zhǔn)Pluvicto?等藥物上市。我國(guó)自主研發(fā)的PSA抑制劑也進(jìn)入Ⅱ期臨床試驗(yàn)階段。

熱銷產(chǎn)品

KLK3 Recombinant Monoclonal Antibody (CSB-RA548583A0HU)

驗(yàn)證數(shù)據(jù)

IHC image of CSB-RA548583A0HU diluted at 1:100 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.