KLK5

KLK5是激肽釋放酶家族中的一種絲氨酸蛋白酶，在人體中發(fā)揮著多重功能。它主要參與皮膚的生理脫屑過程，維持皮膚細(xì)胞的正常更新。然而，KLK5活性的上調(diào)可能引發(fā)連續(xù)的皮膚脫屑，激活蛋白酶激活受體-2（PAR2），導(dǎo)致促炎細(xì)胞因子的釋放，從而破壞表皮屏障功能，與炎癥性皮膚病的發(fā)展密切相關(guān)。此外，KLK5還可能通過剪切Cathelicidin產(chǎn)生活性形式LL-37，參與到玫瑰痤瘡等疾病的免疫調(diào)節(jié)過程中。盡管其具體分子結(jié)構(gòu)和直接參與的信號(hào)通路尚需深入研究，但KLK5在皮膚健康、細(xì)胞增殖、凋亡及免疫調(diào)節(jié)中的重要作用已不容忽視。

熱銷產(chǎn)品

KLK5 Antibody (CSB-PA897100LA01HU)

驗(yàn)證數(shù)據(jù)

Western blot
All lanes: KLK5 antibody at 2μg/ml + MCF-7 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 32 kDa
Observed band size: 32 kDa

Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA897100LA01HU at dilution of 1:100

KLK5 Antibody

KLK5 Protein

KLK5 ELISA Kit

KLK5 Antibodies

KLK5 for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA012456GA01HU	KLK5 Antibody	Human	ELISA
CSB-PA897100LA01HU	KLK5 Antibody	Human	ELISA, WB, IHC
CSB-PA897100LC01HU	KLK5 Antibody, FITC conjugated	Human
CSB-PA175566	KLK5 Antibody	Human,Mouse	ELISA,WB,IHC

KLK5 Proteins

KLK5 Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP897100HU CSB-EP897100HU CSB-BP897100HU CSB-MP897100HU CSB-EP897100HU-B	Recombinant Human Kallikrein-5 (KLK5)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli