KLRD1

KLRD1全稱為殺傷細胞凝集素樣受體亞家族D成員1，常被稱為CD94抗原或NKG2受體復合體組成部分。該蛋白主要分布于自然殺傷細胞（NK細胞）和部分T細胞表面，通過與NKG2家族蛋白（如NKG2A/C）結合形成異源二聚體，參與識別細胞表面的HLA-E分子。這種識別過程在免疫監(jiān)視中發(fā)揮關鍵作用，既能抑制NK細胞對正常組織的攻擊，又能激活對異常細胞（如病毒感染或癌變細胞）的殺傷功能。KLRD1表達水平異常與多種疾病相關，例如類風濕性關節(jié)炎患者的NK細胞中CD94表達顯著升高，而在慢性病毒感染或實體腫瘤微環(huán)境中，受體功能失調可能導致免疫逃逸。針對NK細胞受體的藥物研發(fā)成為熱點，已有抗體藥物通過阻斷抑制性受體（如NKG2A）來增強抗腫瘤免疫，相關療法在頭頸癌、血液腫瘤等領域進入臨床試驗階段。此外，基于CD94/NKG2調控機制的細胞療法也在探索中，為感染性疾病和癌癥提供新的干預策略。

熱銷產(chǎn)品

Recombinant Human Natural killer cells antigen CD94 (KLRD1), partial (CSB-MP615672HU)

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

KLRD1 Antibody (CSB-PA615672LA01HU)

驗證數(shù)據(jù)

Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA615672LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA615672LA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA615672LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

KLRD1 Antibody

KLRD1 Protein

KLRD1 Antibodies

KLRD1 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應性	應用類型
CSB-PA012470GA01HU	KLRD1 Antibody	Human	ELISA,WB
CSB-PA615672LA01HU	KLRD1 Antibody	Human	ELISA, IHC, IF
CSB-PA615672LC01HU	KLRD1 Antibody, FITC conjugated	Human
CSB-PA615672LD01HU	KLRD1 Antibody, Biotin conjugated	Human	ELISA

KLRD1 Proteins

KLRD1 Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP012470RA1 CSB-EP012470RA1 CSB-BP012470RA1 CSB-MP012470RA1 CSB-EP012470RA1-B	Recombinant Rat Natural killer cells antigen CD94 (Klrd1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF012470RA	Recombinant Rat Natural killer cells antigen CD94 (Klrd1)	in vitro E.coli expression system

KLRD1 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP012470MO1 CSB-EP012470MO1 CSB-BP012470MO1 CSB-MP012470MO1 CSB-EP012470MO1-B	Recombinant Mouse Natural killer cells antigen CD94 (Klrd1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF012470MO	Recombinant Mouse Natural killer cells antigen CD94 (Klrd1)	in vitro E.coli expression system

KLRD1 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP615672HU CSB-EP615672HU CSB-BP615672HU CSB-EP615672HU-B	Recombinant Human Natural killer cells antigen CD94 (KLRD1), partial	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-MP615672HU	Recombinant Human Natural killer cells antigen CD94 (KLRD1), partial	Mammalian cell

KLRD1 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP655045DO CSB-EP655045DO CSB-BP655045DO CSB-MP655045DO CSB-EP655045DO-B	Recombinant Dog Natural killer cells antigen CD94 (KLRD1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KLRD1 Proteins for Bos taurus (Bovine)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP768113BO CSB-EP768113BO CSB-BP768113BO CSB-MP768113BO CSB-EP768113BO-B	Recombinant Bovine Natural killer cells antigen CD94 (KLRD1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KLRD1 Proteins for Pongo pygmaeus (Bornean orangutan)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP853978EXP CSB-EP853978EXP CSB-BP853978EXP CSB-MP853978EXP CSB-EP853978EXP-B	Recombinant Pongo pygmaeus Natural killer cells antigen CD94 (KLRD1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KLRD1 Proteins for Macaca mulatta (Rhesus macaque)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP873550MOW CSB-EP873550MOW CSB-BP873550MOW CSB-MP873550MOW CSB-EP873550MOW-B	Recombinant Macaca mulatta Natural killer cells antigen CD94 (KLRD1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KLRD1 Proteins for Pan troglodytes (Chimpanzee)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP882002EQV CSB-EP882002EQV CSB-BP882002EQV CSB-MP882002EQV CSB-EP882002EQV-B	Recombinant Pan troglodytes Natural killer cells antigen CD94 (KLRD1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli