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KLRG1

殺傷細胞凝集素樣受體G1(KLRG1)又稱CLEC15A,是表達于自然殺傷細胞和T細胞表面的免疫抑制性受體。KLRG1通過識別E-鈣黏蛋白等配體傳遞抑制信號,參與調(diào)控免疫細胞活化閾值,在維持免疫穩(wěn)態(tài)中起重要作用。慢性病毒感染患者和腫瘤微環(huán)境中的T細胞常呈現(xiàn)KLRG1高表達,這種終末分化表型與細胞增殖能力下降密切相關(guān),可能影響抗病毒或抗腫瘤免疫應(yīng)答。在自身免疫性疾病領(lǐng)域,KLRG1陽性調(diào)節(jié)性T細胞亞群顯示出更強的免疫抑制功能,其動態(tài)變化與多發(fā)性硬化等疾病進程存在關(guān)聯(lián)。近年針對免疫檢查點的藥物開發(fā)中,KLRG1作為潛在靶點受到關(guān)注,已有研究團隊開發(fā)出阻斷性抗體,在黑色素瘤等動物模型中觀察到聯(lián)合治療可增強PD-1抑制劑療效。但相較于成熟靶點,其轉(zhuǎn)化醫(yī)學(xué)研究仍處于早期階段,配體互作網(wǎng)絡(luò)與下游信號傳導(dǎo)的具體機制尚待深入解析。

熱銷產(chǎn)品

Recombinant Human Killer cell lectin-like receptor subfamily G member 1 (KLRG1), partial (CSB-EP846610HU)

驗證數(shù)據(jù)

CSB-EP846610HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

KLRG1 Recombinant Monoclonal Antibody (CSB-RA233042A0HU)

驗證數(shù)據(jù)

CSB-RA233042A0HU

Overlay Peak curve showing A549 cells surface stained with CSB-RA233042A0HU (red line) at 1:100. The cells were incubated in 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

KLRG1 Antibodies

KLRG1 for Homo sapiens (Human)

KLRG1 Proteins

KLRG1 Proteins for Mus musculus (Mouse)

KLRG1 Proteins for Rattus norvegicus (Rat)

KLRG1 Proteins for Homo sapiens (Human)