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LGR4

LGR4全稱(chēng)為富含亮氨酸重復(fù)序列的G蛋白偶聯(lián)受體4,也被稱(chēng)為GPR48,是人體內(nèi)調(diào)控多種生理過(guò)程的關(guān)鍵受體蛋白。該蛋白通過(guò)與R-spondin家族蛋白結(jié)合,激活Wnt/β-catenin信號(hào)系統(tǒng),參與胚胎發(fā)育、干細(xì)胞自我更新及組織再生等核心生命活動(dòng)。LGR4在腸道隱窩細(xì)胞增殖、骨骼代謝和生殖系統(tǒng)發(fā)育中具有重要作用,其功能異??赡軐?dǎo)致結(jié)直腸癌、骨質(zhì)疏松癥及不孕癥等疾病。例如,結(jié)直腸癌患者中常出現(xiàn)LGR4過(guò)度表達(dá),通過(guò)激活Wnt通路驅(qū)動(dòng)腫瘤生長(zhǎng);而基因敲除小鼠模型則顯示骨密度顯著下降。
近年來(lái)針對(duì)LGR4的藥物開(kāi)發(fā)聚焦于其配體相互作用環(huán)節(jié),已有研究團(tuán)隊(duì)設(shè)計(jì)出阻斷R-spondin與LGR4結(jié)合的小分子化合物,在動(dòng)物實(shí)驗(yàn)中顯示出抑制腫瘤生長(zhǎng)的潛力。同時(shí),基于LGR4在代謝調(diào)控中的作用,研究人員正探索其在糖尿病和肥胖治療中的應(yīng)用價(jià)值。

熱銷(xiāo)產(chǎn)品

Recombinant Human Leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4), partial (CSB-BP883618HU)

驗(yàn)證數(shù)據(jù)

CSB-BP883618HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

LGR4 Antibody (CSB-PA883618LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA883618LA01HU

IHC image of CSB-PA883618LA01HU diluted at 1:100 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA883618LA01HU

Immunofluorescence staining of Hela cells with CSB-PA883618LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

LGR4 Antibodies

LGR4 for Homo sapiens (Human)

LGR4 Proteins

LGR4 Proteins for Mus musculus (Mouse)

LGR4 Proteins for Homo sapiens (Human)