LINGO1
LINGO1全稱為富含亮氨酸重復(fù)序列和免疫球蛋白樣結(jié)構(gòu)域蛋白1，也被稱為LRR蛋白家族成員或神經(jīng)元再生抑制因子。LINGO1在神經(jīng)系統(tǒng)中具有獨特的調(diào)節(jié)功能，特別是在神經(jīng)元生長和髓鞘形成過程中扮演"剎車"角色。LINGO1通過阻礙神經(jīng)突觸延伸和抑制少突膠質(zhì)細胞分化，顯著影響中樞神經(jīng)系統(tǒng)的自我修復(fù)能力。這種特性使其與帕金森病、特發(fā)性震顫等運動障礙類疾病產(chǎn)生關(guān)聯(lián)，部分患者的基因變異可能加劇神經(jīng)退行性病變進程。
近年來針對LINGO1的抑制劑開發(fā)取得突破性進展，多款單克隆抗體藥物已進入臨床試驗階段。其中抗-LINGO1抗體在動物模型中展現(xiàn)出促進髓鞘再生的潛力，二期臨床數(shù)據(jù)顯示其對多發(fā)性硬化癥患者的神經(jīng)功能恢復(fù)具有改善趨勢。此外，小分子化合物篩選工作聚焦于阻斷其與受體間的特異性結(jié)合，為阿爾茨海默病等退行性疾病的治療開辟了新路徑。該靶點的雙重調(diào)節(jié)特性使其成為神經(jīng)保護和再生醫(yī)學(xué)領(lǐng)域的熱門研究對象。
熱銷產(chǎn)品
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
LINGO1 Antibody (CSB-PA839321ESR2HU)
驗證數(shù)據(jù)
Western blot
All lanes: LINGO antibody at 3.12μg/ml
Lane 1: Mouse lung tissue
Lane 2: Jurkat whole cell lysate
Lane 3: A549 whole cell lysate
Lane 4: HL60 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 70 kDa
Observed band size: 70 kDa
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA839321ESR2HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human glioma using CSB-PA839321ESR2HU at dilution of 1:100
LINGO1 Antibodies
LINGO1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA012967GA01HU | LINGO1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA839321ESR2HU | LINGO1 Antibody | Human, Mouse | ELISA, WB, IHC |
LINGO1 Proteins
LINGO1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP839321HU CSB-BP839321HU CSB-MP839321HU CSB-EP839321HU-B |
Recombinant Human Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (LINGO1), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP839321HU | Recombinant Human Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (LINGO1), partial | E.coli |
