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LPL

脂蛋白脂酶(LPL)是調(diào)控血脂代謝的關(guān)鍵水解酶,主要附著在血管內(nèi)皮表面,負(fù)責(zé)分解血液中乳糜微粒和極低密度脂蛋白(VLDL)攜帶的甘油三酯,將其轉(zhuǎn)化為游離脂肪酸供肌肉、脂肪等組織利用。LPL活性異常與多種代謝疾病密切相關(guān),例如家族性LPL基因突變可導(dǎo)致罕見的乳糜微粒血癥綜合征,患者表現(xiàn)為嚴(yán)重高甘油三酯血癥及胰腺炎風(fēng)險(xiǎn)升高。LPL功能缺陷還與動(dòng)脈粥樣硬化、胰島素抵抗等病理過程存在關(guān)聯(lián)。
針對LPL通路的藥物研發(fā)取得突破,Volanesorsen作為反義寡核苷酸藥物,通過抑制載脂蛋白C-III間接增強(qiáng)LPL活性,已在美國獲批用于遺傳性乳糜微粒血癥。靶向ANGPTL3/4蛋白的單克隆抗體可解除其對LPL的天然抑制,這類藥物在降低頑固性高甘油三酯血癥方面展現(xiàn)出潛力。通過激活PPARγ等核受體也可上調(diào)LPL表達(dá),這為糖尿病合并血脂異常提供了新的干預(yù)思路。

熱銷產(chǎn)品

LPL Antibody (CSB-PA013065LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA013065LA01HU

IHC image of CSB-PA013065LA01HU diluted at 1:800 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA013065LA01HU

Immunofluorescence staining of HepG2 cells with CSB-PA013065LA01HU at 1:266, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Human lipoprotein lipase(LPL)ELISA Kit (CSB-E08493h)

驗(yàn)證數(shù)據(jù)

CSB-E08493h 標(biāo)準(zhǔn)曲線

貨號:CSB-E08493h

規(guī)格:96T/48T

靈敏度:7.81 pg/mL

檢測范圍:31.25 pg/mL-2000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

LPL Antibodies

LPL for Homo sapiens (Human)

LPL Proteins

LPL Proteins for Mus musculus (Mouse)

LPL Proteins for Gallus gallus (Chicken)

LPL Proteins for Bos taurus (Bovine)

LPL Proteins for Cavia porcellus (Guinea pig)

LPL Proteins for Sus scrofa (Pig)

LPL Proteins for Felis catus (Cat) (Felis silvestris catus)

LPL Proteins for Homo sapiens (Human)

LPL Proteins for Mustela vison (American mink) (Neovison vison)

LPL Proteins for Papio anubis (Olive baboon)

LPL Proteins for Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)

LPL Proteins for Ovis aries (Sheep)

LPL ELISA Kit

LPL ELISA Kit for Homo sapiens (Human)

LPL ELISA Kit for Mus musculus (Mouse)

LPL ELISA Kit for Rattus norvegicus (Rat)