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LRP6

Low-density lipoprotein receptor-related protein 6 is a protein in humans that is encoded by LRP6 gene. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin.

LRP6 Antibodies

LRP6 for Homo sapiens (Human)

LRP6 Proteins

LRP6 Proteins for Homo sapiens (Human)

LRP6 Proteins for Mus musculus (Mouse)

LRP6 ELISA Kit

LRP6 ELISA Kit for Homo sapiens (Human)