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MAG

髓鞘相關(guān)糖蛋白(Myelin-associated glycoprotein,MAG)是中樞神經(jīng)系統(tǒng)髓鞘的重要組成部分,也被稱為Siglec-4a。它由少突膠質(zhì)細(xì)胞分泌,主要分布在髓鞘最內(nèi)層,通過與神經(jīng)元表面神經(jīng)節(jié)苷脂GD1a/GT1b結(jié)合,在維持軸突髓鞘結(jié)構(gòu)穩(wěn)定中起關(guān)鍵作用。MAG具有抑制神經(jīng)再生的特性,尤其在脊髓損傷后,MAG與Nogo受體結(jié)合后激活下游信號(hào),可阻礙受損軸突的延伸,這一特性使其成為神經(jīng)修復(fù)研究的重點(diǎn)靶點(diǎn)。
MAG異常表達(dá)與多發(fā)性硬化、脊髓損傷后遺癥等脫髓鞘疾病密切相關(guān),其過度抑制作用可能加劇神經(jīng)功能障礙。近年針對(duì)MAG的抗體藥物開發(fā)取得進(jìn)展,例如通過阻斷MAG與其受體的相互作用來(lái)促進(jìn)神經(jīng)再生。目前相關(guān)小分子抑制劑和單抗已進(jìn)入臨床前評(píng)估階段,為治療中樞神經(jīng)損傷提供了新方向。阿爾茨海默病患者腦脊液中檢測(cè)到MAG水平異常升高,提示其可能參與神經(jīng)退行性病變過程。

熱銷產(chǎn)品

Recombinant Human Myelin-associated glycoprotein (MAG), partial (CSB-EP013322HU)

驗(yàn)證數(shù)據(jù)

CSB-EP013322HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-EP013322HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP013322HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) MAG.

CSB-EP013322HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP013322HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) MAG.

MAG Antibody (CSB-PA013322LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA013322LA01HU

Immunofluorescence staining of MCF-7 cells with CSB-PA013322LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CSB-PA013322LA01HU

Western Blot
Positive WB detected in: K562 whole cell lysate, Jurkat whole cell lysate, Rat brain tissue, Mouse brain tissue
All lanes: MAG antibody at 5µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 70, 64, 67 kDa
Observed band size: 70, 100 kDa

CSB-PA013322LA01HU

IHC image of CSB-PA013322LA01HU diluted at 1:600 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA013322LA01HU

IHC image of CSB-PA013322LA01HU diluted at 1:600 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Human myelin-associated glycoprotein(MAG) ELISA Kit (CSB-E17901h)

驗(yàn)證數(shù)據(jù)

CSB-E17901h 標(biāo)準(zhǔn)曲線

貨號(hào):CSB-E17901h

規(guī)格:96T/48T

靈敏度:0.156 ng/mL

檢測(cè)范圍:0.625 ng/mL-40 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

MAG Antibodies

MAG for Homo sapiens (Human)

MAG Proteins

MAG Proteins for Homo sapiens (Human)

MAG Proteins for Mus musculus (Mouse)

MAG Proteins for Rattus norvegicus (Rat)

MAG Proteins for Dermatophagoides farinae (American house dust mite)

MAG Proteins for Arabidopsis thaliana (Mouse-ear cress)

MAG Proteins for Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)

MAG ELISA Kit

MAG ELISA Kit for Homo sapiens (Human)