MAGEA1

MAGEA1，即黑色素瘤相關(guān)抗原家族A1，是一種在多種腫瘤中表達(dá)的蛋白，特別是在黑色素瘤、肺癌、胃癌等惡性腫瘤中。MAGEA1屬于MAGE（melanoma-associated antigen）家族成員，通常在睪丸組織中表達(dá)，而在其他正常組織中表達(dá)較低或不表達(dá)。MAGEA1的作用機(jī)制涉及調(diào)節(jié)細(xì)胞凋亡、影響腫瘤的發(fā)生發(fā)展，其在腫瘤細(xì)胞中的表達(dá)水平與腫瘤的侵襲性和預(yù)后密切相關(guān)。MAGEA1參與的信號(hào)通路包括Wnt/β-catenin信號(hào)通路，它通過(guò)激活該通路促進(jìn)黑色素瘤細(xì)胞的上皮-間充質(zhì)轉(zhuǎn)化（EMT），提高黑色素瘤細(xì)胞的侵襲與遷移能力。此外，MAGEA1還可能參與其他信號(hào)通路，如成纖維細(xì)胞生長(zhǎng)因子受體2（FGFR2）信號(hào)通路，通過(guò)調(diào)節(jié)纖維連接蛋白控制細(xì)胞的增殖和遷移。在生物學(xué)意義上，MAGEA1的異常表達(dá)與腫瘤的增殖、侵襲、轉(zhuǎn)移等過(guò)程密切相關(guān)，是腫瘤治療和免疫治療的潛在靶點(diǎn)。MAGEA1的高表達(dá)通常與腫瘤的不良預(yù)后相關(guān)，其可作為腫瘤生物標(biāo)志物用于診斷和治療監(jiān)測(cè)。

熱銷產(chǎn)品

Recombinant Human Melanoma-associated antigen 1 (MAGEA1) (CSB-YP013323HU)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP013323HU could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) MAGEA1.

MAGEA1 Antibody (CSB-PA013323ESR2HU)

驗(yàn)證數(shù)據(jù)

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA013323ESR2HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA013323ESR2HU at dilution of 1:100

Immunoprecipitating MAGEA1 in Hela whole cell lysate
Lane 1: Rabbit control IgG instead of CSB-PA013323ESR2HU in Hela whole cell lysate. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
Lane 2: CSB-PA013323ESR2HU (8µg) + Hela whole cell lysate (500µg)
Lane 3: Hela whole cell lysate (10µg)

MAGEA1 Antibody

MAGEA1 Protein

MAGEA1 ELISA Kit

MAGEA1 Antibodies

MAGEA1 for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA013323GA01HU	MAGEA1 Antibody	Human	ELISA,WB
CSB-PA013323ESR2HU	MAGEA1 Antibody	Human	ELISA, IHC, IP
CSB-PA003186	MAGEA1 Antibody	Human	WB, IHC, ELISA

MAGEA1 Proteins

MAGEA1 Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP013323HU	Recombinant Human Melanoma-associated antigen 1 (MAGEA1)	Yeast
CSB-MP013323HU	Recombinant Human Melanoma-associated antigen 1 (MAGEA1)	Mammalian cell
CSB-EP013323HU	Recombinant Human Melanoma-associated antigen 1 (MAGEA1)	E.coli
CSB-BP013323HU CSB-EP013323HU-B	Recombinant Human Melanoma-associated antigen 1 (MAGEA1)	Baculovirus In Vivo Biotinylation in E.coli
CSB-MP013323HUd9	Recombinant Human Melanoma-associated antigen 1 (MAGEA1)	Mammalian cell