MAGEA4
MAGEA4，即黑色素瘤相關(guān)抗原A4，別名MAGE-4、MAGE-41、MAGE-X2等。MAGEA4基因?qū)儆贛AGE家族，位于人類的X號染色體上。MAGEA4的作用機(jī)制主要涉及其編碼的蛋白質(zhì)在細(xì)胞內(nèi)的表達(dá)，這些蛋白質(zhì)通常在腫瘤細(xì)胞中表達(dá)，而在正常組織中表達(dá)較低或不表達(dá)，尤其是在睪丸等免疫豁免部位。MAGEA4在腫瘤細(xì)胞中的表達(dá)可能與抑制細(xì)胞凋亡和促進(jìn)腫瘤生長有關(guān)。此外，MAGEA4還可以作為免疫治療的靶點(diǎn)，通過激活針對MAGEA4的免疫反應(yīng)來攻擊腫瘤細(xì)胞。MAGEA4在多種腫瘤中表達(dá)，包括肺癌、卵巢癌、黑色素瘤等，其表達(dá)水平與腫瘤的侵襲性和預(yù)后密切相關(guān)，MAGEA4的檢測和靶向治療具有重要的生物學(xué)意義。
熱銷產(chǎn)品
Recombinant Human Melanoma-associated antigen 4 (MAGEA4) (Active) (CSB-MP013330HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human MAGEA4 at 2 μg/ml can bind anti-MAGEA4 recombinant antibody, the EC50 is 30.33-43.10 ng/mL.
MAGEA4 Antibody (CSB-PA013330LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA013330LA01HU at dilution of 1:100
MAGEA4 Antibodies
MAGEA4 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA013330GA01HU | MAGEA4 Antibody | Human | ELISA,IHC |
| CSB-PA059198 | MAGEA4 Antibody | Human | ELISA,IHC |
| CSB-PA179901 | MAGEA4 Antibody | Human | ELISA,IHC |
| CSB-PA013330LA01HU | MAGEA4 Antibody | Human | ELISA, IHC |
| CSB-PA013330LD01HU | MAGEA4 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA013330LC01HU | MAGEA4 Antibody, FITC conjugated | Human | |
| CSB-PA013330LB01HU | MAGEA4 Antibody, HRP conjugated | Human | ELISA |
| CSB-MA013330A0m | MAGEA4 Monoclonal Antibody | Human | ELISA, IHC, FC |
MAGEA4 Proteins
MAGEA4 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP013330HU CSB-EP013330HU CSB-BP013330HU CSB-EP013330HU-B |
Recombinant Human Melanoma-associated antigen 4 (MAGEA4) | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP013330HU(M) | Recombinant Human Melanoma-associated antigen 4 (MAGEA4) | E.coli |
| CSB-MP013330HU | Recombinant Human Melanoma-associated antigen 4 (MAGEA4) (Active) | Mammalian cell |
| CSB-EP013330HUb0 | Recombinant Human Melanoma-associated antigen 4 (MAGEA4) | E.coli |
