MFAP5
微纖維相關(guān)蛋白5（MFAP5），也被稱為MAGP2，是一種存在于多種組織彈性蛋白網(wǎng)絡(luò)微纖維中的糖蛋白。它在心血管、骨骼肌、腎臟、肺等組織中均有表達，并在脂肪組織中高度表達。MFAP5參與微纖維組裝，有助于維持細胞正常形態(tài)結(jié)構(gòu)，并通過Notch途徑調(diào)節(jié)血管生成，進而影響細胞信號傳導(dǎo)。在病理狀態(tài)下，MFAP5的異常表達與癌癥轉(zhuǎn)移、主動脈瘤的發(fā)生、炎癥代謝異常等過程密切相關(guān)。研究表明，MFAP5在癌癥、主動脈瘤、炎癥相關(guān)疾病以及肥胖和代謝疾病中發(fā)揮重要作用。MFAP5可能通過多種病理途徑參與PCOS代謝紊亂的相關(guān)過程，其水平變化與BMI、空腹血清脂聯(lián)素及瘦素等代謝相關(guān)指標(biāo)相關(guān)，提示其在疾病代謝變化中發(fā)揮重要作用。MFAP5可能通過外周脂肪增多進而影響GnRH分泌，導(dǎo)致高LH水平，這還需后續(xù)研究進一步證實。目前來看，MFAP5參與PCOS的疾病發(fā)生的相關(guān)機制尚未完全闡明，但其作為超重PCOS治療效果的可靠監(jiān)測指標(biāo)，為疾病的治療和預(yù)后提供了新的方向。
熱銷產(chǎn)品
Recombinant Human Microfibrillar-associated protein 5 (MFAP5) (CSB-EP623799HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
驗證數(shù)據(jù)
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA701502(MFAP5 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA701502(MFAP5 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
Human Microfibrillar-associated protein 5(MFAP5) ELISA kit (CSB-EL013750HU)
驗證數(shù)據(jù)
貨號：CSB-EL013750HU
規(guī)格：96T/48T
靈敏度：3.125pg/ml
檢測范圍：12.5pg/ml - 800pg/ml
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
MFAP5 Antibodies
MFAP5 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA013750GA01HU | MFAP5 Antibody | Human | ELISA,WB,IHC |
| CSB-PA623799LA01HU | MFAP5 Antibody | Human | ELISA, IHC |
| CSB-PA701502 | MFAP5 Antibody | Human | ELISA,IHC |
MFAP5 Proteins
MFAP5 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP623799HU CSB-BP623799HU CSB-MP623799HU CSB-EP623799HU-B |
Recombinant Human Microfibrillar-associated protein 5 (MFAP5) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP623799HU | Recombinant Human Microfibrillar-associated protein 5 (MFAP5) | E.coli |
MFAP5 ELISA Kit
MFAP5 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL013750HU | Human Microfibrillar-associated protein 5(MFAP5) ELISA kit | serum, plasma, tissue homogenates | 3.125pg/ml |
