MGA

MGA，即MAX二聚化蛋白MGA，別名MAD5、MXD5。它在人體中廣泛表達(dá)，尤其在卵巢、睪丸等組織中表達(dá)量較高。MGA是一種雙特異的轉(zhuǎn)錄因子，含有3042個(gè)氨基酸，參與細(xì)胞命運(yùn)規(guī)范和RNA聚合酶II對(duì)轉(zhuǎn)錄的正調(diào)控。MGA在維持胚胎干細(xì)胞的多能性以及胚胎發(fā)育早期起著重要作用，是多梳抑制復(fù)合物PRC1.6的一個(gè)組分，通過(guò)穩(wěn)定PRC1.6復(fù)合物來(lái)發(fā)揮作用，主要沉默原始內(nèi)胚層關(guān)鍵基因Gata4/6及Sox17，避免胚胎干細(xì)胞向原始內(nèi)胚層的轉(zhuǎn)變。MGA的功能異常與多種疾病相關(guān)，包括腫瘤和發(fā)育異常。MGA對(duì)于早期胚胎發(fā)育和細(xì)胞命運(yùn)決定具有關(guān)鍵作用，其研究有助于深入理解胚胎早期細(xì)胞命運(yùn)決定的分子機(jī)制。

熱銷產(chǎn)品

Recombinant Human Maltase-glucoamylase (MGAM), partial (CSB-BP013772HU(A5))

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

The purity of MGAM was greater than 90% as determined by SEC-HPLC

MGA Protein

MGA ELISA Kit

MGA Proteins

MGA Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP013772HU CSB-EP013772HU CSB-BP013772HU CSB-MP013772HU CSB-EP013772HU-B	Recombinant Human Maltase-glucoamylase (MGAM), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP814215HU CSB-EP814215HU CSB-BP814215HU CSB-MP814215HU CSB-EP814215HU-B	Recombinant Human MAX gene-associated protein (MGA), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-BP013772HU(A4)	Recombinant Human Maltase-glucoamylase (MGAM), partial	Baculovirus
CSB-BP013772HU(A5)	Recombinant Human Maltase-glucoamylase (MGAM), partial	Baculovirus
CSB-EP013772HU(A4)	Recombinant Human Maltase-glucoamylase, intestinal (MGAM), partial	E.coli

MGA Proteins for Mus musculus (Mouse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP381793MO CSB-EP381793MO CSB-BP381793MO CSB-MP381793MO CSB-EP381793MO-B	Recombinant Mouse MAX gene-associated protein (Mga), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli