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MMP12

MMP12,即基質(zhì)金屬肽酶12,別名Macrophageelastase。它是一種主要由成熟組織巨噬細(xì)胞表達(dá)的酶,屬于基質(zhì)金屬蛋白酶家族成員之一。MMP12的作用機(jī)制涉及降解多種細(xì)胞外基質(zhì)成分,如Ⅳ型膠原、硫酸軟骨素、層粘連蛋白及纖溶酶原等。MMP12參與腫瘤細(xì)胞的侵襲和轉(zhuǎn)移,促進(jìn)多種腫瘤如鼻咽癌、結(jié)直腸癌等的侵襲和轉(zhuǎn)移,同時(shí)也參與許多肺部疾病的病理過程,如慢性阻塞性肺疾病、過敏性哮喘、肺氣腫、肺纖維化和肺部感染等。MMP12還與動(dòng)脈粥樣硬化斑塊的進(jìn)展和不穩(wěn)定性相關(guān),并可能參與動(dòng)脈粥樣硬化性腦梗死及冠心病的病理過程。MMP12在病理學(xué)研究和疾病治療中具有重要的生物學(xué)意義和潛在的治療應(yīng)用價(jià)值。

熱銷產(chǎn)品

Recombinant Human Macrophage metalloelastase (MMP12) (CSB-EP014659HU)

驗(yàn)證數(shù)據(jù)

CSB-EP014659HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-EP014659HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP014659HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) MMP12.

CSB-EP014659HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP014659HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) MMP12.

MMP12 Recombinant Monoclonal Antibody (CSB-RA595609A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA595609A0HU

Western Blot
Positive WB detected in: 293T whole cell lysate, MCF-7 whole cell lysate, THP-1 whole cell lysate
All lanes: MMP12 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 55 kDa
Observed band size: 54, 45 kDa

CSB-RA595609A0HU

IHC image of CSB-RA595609A0HU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

Human Matrix Metalloproteinase 12(MMP-12) ELISA Kit (CSB-E13208h)

驗(yàn)證數(shù)據(jù)

CSB-E13208h 標(biāo)準(zhǔn)曲線

貨號(hào):CSB-E13208h

規(guī)格:96T/48T

靈敏度:0.156 ng/mL

檢測(cè)范圍:0.625 ng/mL-40 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

MMP12 Antibodies

MMP12 for Homo sapiens (Human)

MMP12 Proteins

MMP12 Proteins for Homo sapiens (Human)

MMP12 ELISA Kit

MMP12 ELISA Kit for Homo sapiens (Human)