MSLN
MSLN，即間皮素（Mesothelin），是一種糖基磷脂酰肌醇(GPI)錨定的細(xì)胞表面糖蛋白，由MSLN基因編碼的前蛋白經(jīng)過蛋白水解后產(chǎn)生巨核細(xì)胞增強(qiáng)因子和間皮素兩種蛋白產(chǎn)物。
MSLN的作用機(jī)制涉及其在細(xì)胞表面的表達(dá)，通過與配體如CA125/MUC16的高親和力相互作用促進(jìn)異型細(xì)胞粘附，進(jìn)而影響腫瘤的轉(zhuǎn)移。此外，MSLN的過表達(dá)能夠激活NF-κB、MAPK和PI3K-激酶促進(jìn)細(xì)胞增殖和抵抗凋亡的細(xì)胞內(nèi)通路。MSLN在正常組織中的表達(dá)有限，但在卵巢癌、乳腺癌、結(jié)直腸癌和胰腺癌等幾種實(shí)體腫瘤中的過度表達(dá)，與較低的存活率相關(guān)，是腫瘤特異性治療的理想靶點(diǎn)。
熱銷產(chǎn)品
Recombinant Human Mesothelin (MSLN), partial (Active) (CSB-MP015044HUc9)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized MSLN at 2 μg/ml can bind Anti-MSLN rabbit monoclonal antibody, the EC50 of the MSLN protein is 2.657-3.177 ng/ml.
Activity
Measured by its binding ability in a functional ELISA. Immobilized MUC16(CSB-MP704410HU3c7) at 10 μg/ml can bind MSLN, the EC50 is 460.7-662.2 ng/ml.
MSLN Antibody (CSB-PA015044ESR1HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: MSLN antibody at 8µg/ml + Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 69, 72, 68 kDa
Observed band size: 69 kDa
Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA015044ESR1HU at dilution of 1:100
MSLN Antibodies
MSLN for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA015044LA01MO | Msln Antibody | Mouse | ELISA |
| CSB-PA015044LB01MO | Msln Antibody, HRP conjugated | Mouse | ELISA |
| CSB-PA015044LC01MO | Msln Antibody, FITC conjugated | Mouse | |
| CSB-PA015044LD01MO | Msln Antibody, Biotin conjugated | Mouse | ELISA |
MSLN for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA10159A0Rb | MSLN Antibody | Human | ELISA, IHC, IF, IP |
| CSB-PA10159B0Rb | MSLN Antibody, HRP conjugated | Human | ELISA |
| CSB-PA10159C0Rb | MSLN Antibody, FITC conjugated | Human | |
| CSB-PA10159D0Rb | MSLN Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA015044ESR1HU | MSLN Antibody | Human | ELISA, WB, IHC |
| CSB-PA015044ESR2HU | MSLN Antibody | Human | ELISA, IHC |
| CSB-PA846777 | MSLN Antibody | Human | ELISA,IHC |
| CSB-PA952111 | MSLN Antibody | Human | ELISA,IHC |
MSLN Proteins
MSLN Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP015044MO | Recombinant Mouse Mesothelin (Msln), partial | Yeast |
| CSB-EP015044MO | Recombinant Mouse Mesothelin (Msln), partial | E.coli |
| CSB-BP015044MO CSB-MP015044MO CSB-EP015044MO-B |
Recombinant Mouse Mesothelin (Msln), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MSLN Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP015044RA CSB-EP015044RA CSB-BP015044RA CSB-MP015044RA CSB-EP015044RA-B |
Recombinant Rat Mesothelin (Msln) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MSLN Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-MP015044HU | Recombinant Human Mesothelin (MSLN), partial | Mammalian cell |
| CSB-MP015044HUf3 | Recombinant Human Mesothelin (MSLN), partial | Mammalian cell |
| CSB-MP015044HUc9 | Recombinant Human Mesothelin (MSLN), partial (Active) | Mammalian cell |
| CSB-MP015044HU-B | Recombinant Human Mesothelin (MSLN), partial,Biotinylated | Mammalian cell |
MSLN ELISA Kit
MSLN ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E13382h | Human Mesothelin(MSLN)ELISA KIT | serum, plasma, tissue homogenates | 15.6 pg/mL |
