MT1A
金屬硫蛋白1A（Metallothionein 1A，簡稱MT1A）是一類廣泛存在于人體組織的小分子蛋白，因其富含半胱氨酸殘基也被稱作"金屬結(jié)合衛(wèi)士"。MT1A通過螯合鋅、銅等必需金屬離子，維持細(xì)胞內(nèi)環(huán)境穩(wěn)定，同時(shí)能高效中和重金屬毒性物質(zhì)如鎘和汞，在肝臟解毒過程中發(fā)揮核心作用。其抗氧化特性對(duì)抵御自由基損傷、延緩細(xì)胞衰老具有重要價(jià)值。
MT1A表達(dá)異常與多種病理狀態(tài)相關(guān)。在阿爾茨海默病、帕金森病等神經(jīng)退行性疾病中，患者腦部MT1A水平顯著下降，提示其可能參與神經(jīng)保護(hù)過程。肝癌、乳腺癌等惡性腫瘤組織常出現(xiàn)該蛋白的異常高表達(dá)，可能與腫瘤細(xì)胞抵抗化療藥物及適應(yīng)缺氧微環(huán)境有關(guān)。近年針對(duì)MT1A的調(diào)控策略逐漸受到關(guān)注，包括利用其作為重金屬中毒的生物標(biāo)志物，開發(fā)基于金屬硫蛋白結(jié)構(gòu)的仿生解毒劑，以及探索通過表觀遺傳手段調(diào)節(jié)其表達(dá)來增強(qiáng)抗癌療效。天然產(chǎn)物如姜黃素已被證實(shí)可誘導(dǎo)MT1A生成，為抗氧化治療提供了新思路。
熱銷產(chǎn)品
Recombinant Human Metallothionein-1A (MT1A), partial (CSB-EP015107HU1)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
MT1A Antibody (CSB-PA17444A0Rb)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA17444A0Rb at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA17444A0Rb at dilution of 1:100
Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA17444A0Rb at dilution of 1:100
Human Metallothionein,MT ELISA Kit (CSB-E09060h)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-E09060h
規(guī)格：96T/48T
靈敏度：0.813 pg/mL
檢測范圍：6.25 pg/mL-400 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
MT1A Antibodies
MT1A for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA17444C0Rb | MT1A Antibody, FITC conjugated | Human | |
| CSB-PA17444A0Rb | MT1A Antibody | Human | ELISA, IHC |
MT1A Proteins
MT1A Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP015107HU CSB-EP015107HU CSB-BP015107HU CSB-MP015107HU CSB-EP015107HU-B |
Recombinant Human Metallothionein-1A (MT1A) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP015107HU1 | Recombinant Human Metallothionein-1A (MT1A), partial | E.coli |
MT1A ELISA Kit
MT1A ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E09060h | Human Metallothionein,MT ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates, urine, saliva | 0.813 pg/mL |
