MYC
MYC全稱為myelocytomatosis oncogene，又名c-Myc、v-myc或BHLHE39，是調控細胞增殖的核心轉錄因子。MYC通過結合MAX蛋白形成異源二聚體，特異性識別DNA的E-box序列，激活涉及細胞周期進程、代謝重編程和凋亡抑制的靶基因表達。其在胚胎發(fā)育和組織再生中起關鍵作用，異常激活可導致超過70%的人類腫瘤發(fā)生，包括伯基特淋巴瘤、神經母細胞瘤和多種實體瘤。Wnt、Notch等發(fā)育通路常與MYC形成調控網絡，而PI3K/AKT/mTOR通路則介導其促癌效應。
當前針對MYC的直接抑制劑尚未上市，但通過表觀遺傳調控的BET蛋白抑制劑（如OTX015）已進入血液腫瘤的II期臨床試驗。小分子化合物MYCi975通過破壞MYC/MAX相互作用進入臨床前研究，同時針對MYC蛋白穩(wěn)定性的aurora激酶抑制劑Alisertib在乳腺癌治療中顯示出協(xié)同效應。反義寡核苷酸藥物如AZD9150曾嘗試阻斷MYC mRNA，但因療效有限終止研發(fā)。近年來CRISPR基因編輯技術和PROTAC降解劑為靶向MYC提供了新思路，其中MTX-216等候選藥物正在評估中。
熱銷產品
Recombinant Human Myc proto-oncogene protein (MYC),Biotinylated (CSB-EP015270HU-B)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
MYC Recombinant Monoclonal Antibody (CSB-RA914333A0HU)
驗證數(shù)據(jù)
Overlay histogram showing Hela cells stained with CSB-RA914333A0HU (red line) at 1:50. The cells were fixed with 70% Ethylalcohol (18h) and then incubated in 10% normal goat serum to block non-specific protein-protein interactions followedby the antibody (1μg/1*106 cells) for 1 h at 4℃.The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 30min at 4℃. Control antibody (green line) was Rabbit IgG (1μg/1*106 cells) used under the same conditions. Acquisition of >10,000 events was performed.
Human c-myc Oncogene product,c-myc ELISA Kit (CSB-E09260h)
驗證數(shù)據(jù)
貨號：CSB-E09260h
規(guī)格：96T/48T
靈敏度：0.078 ng/mL
檢測范圍：0.312 ng/mL-20 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
MYC Antibodies
MYC for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA015270EA01MO | Myc Antibody | Mouse | ELISA |
| CSB-PA015270EB01MO | Myc Antibody, HRP conjugated | Mouse | ELISA |
| CSB-PA015270EC01MO | Myc Antibody, FITC conjugated | Mouse | |
| CSB-PA015270ED01MO | Myc Antibody, Biotin conjugated | Mouse | ELISA |
MYC for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA015270GA01HU | MYC Antibody | Human,Mouse,Rat | ELISA,WB, IP, IHC, IF, FC |
| CSB-PA945395 | Phospho-MYC (Thr58) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA239396 | Phospho-MYC (Thr358) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA038920 | Phospho-MYC (Ser373) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA062361 | Phospho-MYC (Ser62) Antibody | Human,Mouse,Rat | ELISA,WB,IF |
| CSB-PA598712 | MYC (Ab-58) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA930453 | MYC (Ab-358) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA552586 | MYC (Ab-373) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA153029 | MYC Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA000389 | MYC Antibody | Human | WB |
| CSB-PA000503 | Phospho-MYC (T58) Antibody | Human,Mouse,Rat | WB, IHC, IP, ELISA |
| CSB-PA000729 | Phospho-MYC (S62) Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA001729 | MYC Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA010301 | Phospho-MYC (S373) Antibody | Human,Mouse,Rat | IHC, IP, ELISA |
| CSB-PA010303 | Phospho-MYC (T358) Antibody | Human,Mouse,Rat | IHC, IP, ELISA |
| CSB-PA407491 | MYC Antibody | Human,Rat | ELISA,WB,IHC |
| CSB-PA02589A0Rb | MYC Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA02589B0Rb | MYC Antibody, HRP conjugated | Human | ELISA |
| CSB-PA02589C0Rb | MYC Antibody, FITC conjugated | Human | |
| CSB-PA02589D0Rb | MYC Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA015270A58-62phHU | Phospho-MYC (T58+S62) Recombinant Monoclonal Antibody | Human | ELISA, WB |
| CSB-RA015270A62phHU | Phospho-MYC (S62) Recombinant Monoclonal Antibody | Human | ELISA, WB, IF |
| CSB-RA914333A0HU | MYC Recombinant Monoclonal Antibody | Human | ELISA, FC |
| CSB-MA015270A0m | MYC Monoclonal Antibody | Human | ELISA, WB |
MYC Proteins
MYC Proteins for Felis catus (Cat) (Felis silvestris catus)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP015270CA CSB-EP015270CA CSB-BP015270CA CSB-MP015270CA CSB-EP015270CA-B |
Recombinant Cat Myc proto-oncogene protein (MYC) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYC Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP015270MO CSB-BP015270MO CSB-MP015270MO CSB-EP015270MO-B |
Recombinant Mouse Myc proto-oncogene protein (Myc) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP015270MO | Recombinant Mouse Myc proto-oncogene protein (Myc) | E.coli |
MYC Proteins for Gallus gallus (Chicken)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP015270CH CSB-EP015270CH CSB-BP015270CH CSB-MP015270CH CSB-EP015270CH-B |
Recombinant Chicken Myc proto-oncogene protein (MYC) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYC Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP015270HU CSB-BP015270HU CSB-MP015270HU |
Recombinant Human Myc proto-oncogene protein (MYC) | Yeast Baculovirus Mammalian cell |
| CSB-EP015270HU | Recombinant Human Myc proto-oncogene protein (MYC) | E.coli |
| CSB-EP015270HU1 | Recombinant Human Myc proto-oncogene protein (MYC), partial | E.coli |
MYC Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP015270RA CSB-EP015270RA CSB-BP015270RA CSB-MP015270RA CSB-EP015270RA-B |
Recombinant Rat Myc proto-oncogene protein (Myc) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYC Proteins for Macaca mulatta (Rhesus macaque)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP015270MOW CSB-EP015270MOW CSB-BP015270MOW CSB-MP015270MOW CSB-EP015270MOW-B |
Recombinant Macaca mulatta (Rhesus macaque) Myc proto-oncogene protein (MYC) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYC Proteins for Marmota monax (Woodchuck)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP015270MQG CSB-EP015270MQG CSB-BP015270MQG CSB-MP015270MQG CSB-EP015270MQG-B |
Recombinant Marmota monax Myc proto-oncogene protein (MYC) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYC Proteins for Pan troglodytes (Chimpanzee)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP015270EQV CSB-EP015270EQV CSB-BP015270EQV CSB-MP015270EQV CSB-EP015270EQV-B |
Recombinant Pan troglodytes Myc proto-oncogene protein (MYC) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYC Proteins for Callithrix jacchus (White-tufted-ear marmoset)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP015270CYL CSB-EP015270CYL CSB-BP015270CYL CSB-MP015270CYL CSB-EP015270CYL-B |
Recombinant Callithrix jacchus Myc proto-oncogene protein (MYC) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYC Proteins for Hylobates lar (Common gibbon)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP015270HXW CSB-EP015270HXW CSB-BP015270HXW CSB-MP015270HXW CSB-EP015270HXW-B |
Recombinant Hylobates lar Myc proto-oncogene protein (MYC) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYC Proteins for Pan paniscus (Pygmy chimpanzee) (Bonobo)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP015270EQU CSB-EP015270EQU CSB-BP015270EQU CSB-MP015270EQU CSB-EP015270EQU-B |
Recombinant Pan paniscus Myc proto-oncogene protein (MYC) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYC Proteins for Pongo pygmaeus (Bornean orangutan)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP015270EXP CSB-EP015270EXP CSB-BP015270EXP CSB-MP015270EXP CSB-EP015270EXP-B |
Recombinant Pongo pygmaeus Myc proto-oncogene protein (MYC) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYC Proteins for Feline leukemia virus
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP303036FAN CSB-EP303036FAN CSB-BP303036FAN CSB-MP303036FAN CSB-EP303036FAN-B |
Recombinant Viral myc transforming protein (MYC) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYC Proteins for Avian retrovirus MH2
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP314892ASY CSB-EP314892ASY CSB-BP314892ASY CSB-MP314892ASY CSB-EP314892ASY-B |
Recombinant Viral myc transforming protein (MYC) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYC Proteins for Avian myelocytomatosis virus CMII
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP319189ASR CSB-EP319189ASR CSB-BP319189ASR CSB-MP319189ASR CSB-EP319189ASR-B |
Recombinant Viral myc transforming protein (MYC) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYC Proteins for Avian retrovirus OK10
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP319420ATB CSB-EP319420ATB CSB-BP319420ATB CSB-MP319420ATB CSB-EP319420ATB-B |
Recombinant Viral myc transforming protein (MYC) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYC Proteins for Feline leukemia virus FTT
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP325084FAT CSB-EP325084FAT CSB-BP325084FAT CSB-MP325084FAT CSB-EP325084FAT-B |
Recombinant Viral myc transforming protein (MYC) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYC Proteins for Carassius auratus (Goldfish)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP343029DQG CSB-EP343029DQG CSB-BP343029DQG CSB-MP343029DQG CSB-EP343029DQG-B |
Recombinant Carassius auratus Transcriptional regulator Myc (myc) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYC Proteins for Avian myelocytomatosis virus HBI
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP356768ASS CSB-EP356768ASS CSB-BP356768ASS CSB-MP356768ASS CSB-EP356768ASS-B |
Recombinant Viral myc transforming protein (MYC) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYC Proteins for Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP361904OEI CSB-EP361904OEI CSB-BP361904OEI CSB-MP361904OEI CSB-EP361904OEI-B |
Recombinant Oncorhynchus mykiss Transcriptional regulator Myc (myc) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYC Proteins for Avian myelocytomatosis virus MC29
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP365521AST CSB-EP365521AST CSB-BP365521AST CSB-MP365521AST CSB-EP365521AST-B |
Recombinant Viral myc transforming protein (MYC) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYC Proteins for Avian retrovirus MH2E21
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP366221ASZ CSB-EP366221ASZ CSB-BP366221ASZ CSB-MP366221ASZ CSB-EP366221ASZ-B |
Recombinant Viral myc transforming protein (MYC) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYC Proteins for Asterias rubens (Common European starfish) (Asterias vulgaris)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP613744AQB CSB-EP613744AQB CSB-BP613744AQB CSB-MP613744AQB CSB-EP613744AQB-B |
Recombinant Asterias rubens Myc protein (MYC) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYC Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP634666DO CSB-EP634666DO CSB-BP634666DO CSB-MP634666DO CSB-EP634666DO-B |
Recombinant Dog Myc proto-oncogene protein (MYC) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYC Proteins for Ovis aries (Sheep)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP638936SH CSB-EP638936SH CSB-BP638936SH CSB-MP638936SH CSB-EP638936SH-B |
Recombinant Sheep Myc proto-oncogene protein (MYC) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYC Proteins for Sus scrofa (Pig)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP644899PI CSB-EP644899PI CSB-BP644899PI CSB-MP644899PI CSB-EP644899PI-B |
Recombinant Pig Myc proto-oncogene protein (MYC) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYC Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP645319BO CSB-EP645319BO CSB-BP645319BO CSB-MP645319BO CSB-EP645319BO-B |
Recombinant Bovine Myc proto-oncogene protein (MYC) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYC Proteins for Sylvilagus floridanus (Cottontail rabbit)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP863072FPT CSB-EP863072FPT CSB-BP863072FPT CSB-MP863072FPT CSB-EP863072FPT-B |
Recombinant Sylvilagus floridanus Myc proto-oncogene protein (MYC) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYC Proteins for Pteropus hypomelanus (Island flying fox) (Variable flying fox)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP865037PLAH CSB-EP865037PLAH CSB-BP865037PLAH CSB-MP865037PLAH CSB-EP865037PLAH-B |
Recombinant Pteropus hypomelanus Myc proto-oncogene protein (MYC) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYC Proteins for Galeopterus variegatus (Malayan flying lemur) (Cynocephalus variegatus)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP873552GAG CSB-EP873552GAG CSB-BP873552GAG CSB-MP873552GAG CSB-EP873552GAG-B |
Recombinant Galeopterus variegatus Myc proto-oncogene protein (MYC) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYC Proteins for Tupaia glis (Tree shrew)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP885626TJH CSB-EP885626TJH CSB-BP885626TJH CSB-MP885626TJH CSB-EP885626TJH-B |
Recombinant Tupaia glis Myc proto-oncogene protein (MYC) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYC Proteins for Tadarida brasiliensis (Brazilian free-tailed bat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP889010TAI CSB-EP889010TAI CSB-BP889010TAI CSB-MP889010TAI CSB-EP889010TAI-B |
Recombinant Tadarida brasiliensis Myc proto-oncogene protein (MYC) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYC Proteins for Drosophila melanogaster (Fruit fly)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP894777DLU CSB-EP894777DLU CSB-BP894777DLU CSB-MP894777DLU CSB-EP894777DLU-B |
Recombinant Drosophila melanogaster Myc protein (dm), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYC ELISA Kit
MYC ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E09260h | Human c-myc Oncogene product,c-myc ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 0.078 ng/mL |
