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NEFL

神經(jīng)纖維絲輕鏈（NEFL）是神經(jīng)元軸突的主要細(xì)胞骨架蛋白，對維持神經(jīng)元形態(tài)和信號傳導(dǎo)至關(guān)重要。正常生理條件下，軸突釋放少量NEFL，但在病理條件下，其釋放量顯著增加。組織液中的NEFL可通過腦脊液擴(kuò)散至血液，血液中NEFL濃度較腦脊液低，且與神經(jīng)病變程度密切相關(guān)，因此NEFL被用作神經(jīng)元損傷相關(guān)疾病的生物標(biāo)志物。在阿爾茨海默病、帕金森病、肌萎縮側(cè)索硬化癥等神經(jīng)退行性疾病中，血液中的NEFL水平都會上升。此外，NEFL水平也隨年齡增長而上升，可作為疾病診斷和預(yù)后監(jiān)測的指標(biāo)。目前，針對NEFL的藥物研發(fā)尚處于早期階段，但其在神經(jīng)疾病診斷和監(jiān)測中的應(yīng)用前景廣闊。

熱銷產(chǎn)品

Recombinant Human Neurofilament light polypeptide (NEFL) (CSB-CF015688HU)

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

NEFL Antibody (CSB-PA015688LA01HU)

驗證數(shù)據(jù)

Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA015688LA01HU at dilution of 1:100

Immunofluorescent analysis of SH-SY5Y cells using CSB-PA015688LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Immunoprecipitating NEFL in mouse brain tissue
Lane 1: Rabbit control IgG instead of CSB-PA015688LA01HU in mouse brain tissue. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
Lane 2: CSB-PA015688LA01HU (8μg) + Mouse brain tissue (500μg)
Lane 3: Mouse brain tissue (10μg)

Human Neurofilament protein L (NF-L) ELISA kit (CSB-E16094h)

驗證數(shù)據(jù)

貨號：CSB-E16094h

規(guī)格：96T/48T

靈敏度：7.8 pg/mL

檢測范圍：31.25 pg/mL-2000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

NEFL Antibody

NEFL Protein

NEFL ELISA Kit

NEFL Antibodies

NEFL for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA015688GA01HU	NEFL Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IF
CSB-PA004743	NEFL Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA020052	NEFL Antibody	Human,Mouse,Rat	IHC, ELISA
CSB-PA146631	NEFL Antibody	Human	ELISA,IHC
CSB-PA015688LA01HU	NEFL Antibody	Human	ELISA, IHC, IF, IP
CSB-PA015688LB01HU	NEFL Antibody, HRP conjugated	Human	ELISA
CSB-PA015688LC01HU	NEFL Antibody, FITC conjugated	Human
CSB-PA015688LD01HU	NEFL Antibody, Biotin conjugated	Human	ELISA

NEFL Proteins

NEFL Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP015688MO	Recombinant Mouse Neurofilament light polypeptide (Nefl)	Yeast
CSB-BP015688MO CSB-MP015688MO CSB-EP015688MO-B	Recombinant Mouse Neurofilament light polypeptide (Nefl)	Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP015688MOe1	Recombinant Mouse Neurofilament light polypeptide (Nefl)	E.coli
CSB-EP015688MO	Recombinant Mouse Neurofilament light polypeptide (Nefl)	E.coli

NEFL Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP015688HU CSB-BP015688HU CSB-EP015688HU-B	Recombinant Human Neurofilament light polypeptide (NEFL)	Yeast Baculovirus In Vivo Biotinylation in E.coli
CSB-EP015688HU	Recombinant Human Neurofilament light polypeptide (NEFL)	E.coli
CSB-EP015688HUe1	Recombinant Human Neurofilament light polypeptide (NEFL)	E.coli
CSB-EP015688HU1	Recombinant Human Neurofilament light polypeptide (NEFL),Partial	E.coli
CSB-EP015688HUc7	Recombinant Human Neurofilament light polypeptide (NEFL)	E.coli

NEFL Proteins for Pongo abelii (Sumatran orangutan)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP719095PYX CSB-EP719095PYX CSB-BP719095PYX CSB-MP719095PYX CSB-EP719095PYX-B	Recombinant Pongo abelii Neurofilament light polypeptide (NEFL), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli