NF2
NF2，即神經(jīng)纖維瘤病2型，別名 ACN、BANF、Merlin。它來源于一種名為NF2的基因突變，這種突變主要影響位于22號染色體上的NF2基因，該基因編碼的Merlin蛋白具有腫瘤抑制功能。當(dāng)NF2基因發(fā)生突變時(shí)，Merlin蛋白的功能受損，導(dǎo)致細(xì)胞對腫瘤生長的抑制作用減弱，進(jìn)而增加神經(jīng)系統(tǒng)腫瘤（如前庭神經(jīng)鞘瘤、腦膜瘤等）的風(fēng)險(xiǎn)。NF2揭示了特定基因突變與神經(jīng)系統(tǒng)腫瘤發(fā)生之間的關(guān)聯(lián)，為疾病的早期診斷、治療和遺傳咨詢提供了重要依據(jù)。
熱銷產(chǎn)品
Recombinant Human Merlin (NF2) (CSB-EP015741HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
NF2 Antibody (CSB-PA015741LA01HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: HEK293 whole cell lysate, Jurkat whole cell lysate, MCF-7 whole cell lysate, NIH/3T3 whole cell lysate
All lanes: NF2 antibody at 2.6μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 70, 73, 60, 65, 64, 31, 66, 20, 25 kDa
Observed band size: 70, 73 kDa
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA015741LA01HU at dilution of 1:100
Immunofluorescent analysis of Hela cells using CSB-PA015741LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
NF2 Antibodies
NF2 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA015741GA01HU | NF2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA149148 | Phospho-NF2 (Ser518) Antibody | Human,Mouse,Rat | ELISA,WB,IF |
| CSB-PA779103 | NF2 (Ab-518) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA249373 | NF2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA003420 | NF2 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA020074 | Phospho-NF2 (S518) Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA020075 | Phospho-NF2 (S10) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA020077 | NF2 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA015741LA01HU | NF2 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA015741LB01HU | NF2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA015741LC01HU | NF2 Antibody, FITC conjugated | Human | |
| CSB-PA015741LD01HU | NF2 Antibody, Biotin conjugated | Human | ELISA |
NF2 Proteins
NF2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP015741HU CSB-BP015741HU CSB-MP015741HU CSB-EP015741HU-B |
Recombinant Human Merlin (NF2) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP015741HU | Recombinant Human Merlin (NF2) | E.coli |
NF2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP015741MO1 CSB-BP015741MO1 CSB-MP015741MO1 CSB-EP015741MO1-B |
Recombinant Mouse Merlin (Nf2), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP015741MO1 | Recombinant Mouse Merlin (Nf2), partial | E.coli |
NF2 Proteins for Papio anubis (Olive baboon)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP015741ERI CSB-EP015741ERI CSB-BP015741ERI CSB-MP015741ERI CSB-EP015741ERI-B |
Recombinant Papio anubis Merlin (NF2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NF2 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP726923RA CSB-EP726923RA CSB-BP726923RA CSB-MP726923RA CSB-EP726923RA-B |
Recombinant Rat Merlin (Nf2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
