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NFATC1

NFATC1,即核因子活化T細胞1,別名NFAT2、NFATc、NF-ATC、NF-ATc1.2等。它是一種由NFATC1基因編碼的轉(zhuǎn)錄因子,主要在免疫細胞如T細胞和B細胞中表達,對免疫應(yīng)答中的基因轉(zhuǎn)錄調(diào)控起關(guān)鍵作用。NFATC1的作用機制涉及鈣調(diào)磷酸酶的激活,導(dǎo)致其從細胞質(zhì)轉(zhuǎn)移到細胞核,進而調(diào)控靶基因的表達。NFATC1參與調(diào)節(jié)免疫反應(yīng)、細胞增殖、分化和遷移等過程,對維持免疫系統(tǒng)平衡至關(guān)重要。異常的NFATC1表達與多種疾病相關(guān),包括自身免疫疾病、心血管疾病和腫瘤等。

熱銷產(chǎn)品

NFATC1 Antibody (CSB-PA17827A0Rb)

驗證數(shù)據(jù)

CSB-PA17827A0Rb

IHC image of CSB-PA17827A0Rb diluted at 1:1200 and staining in paraffin-embedded human appendix tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA17827A0Rb

Immunofluorescent analysis of HepG2 cells using CSB-PA17827A0Rb at dilution of 1: 100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

NFATC1 Antibodies

NFATC1 for Homo sapiens (Human)

NFATC1 Proteins

NFATC1 Proteins for Bos taurus (Bovine)

NFATC1 Proteins for Sus scrofa (Pig)

NFATC1 Proteins for Mus musculus (Mouse)

NFATC1 Proteins for Homo sapiens (Human)