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NLRP10

NLRP10,即含NLR家族pyrin結(jié)構(gòu)域10,別名NOD8、PAN5、PYNOD、NALP10、CLR11.1。NLRP10作為信號(hào)誘導(dǎo)的多蛋白復(fù)合體(炎癥小體)的一部分,激活促炎半胱天冬酶caspase-1和caspase-5,同時(shí)NLRP10也被認(rèn)為是炎癥和細(xì)胞凋亡的多功能負(fù)調(diào)節(jié)因子。NLRP10在先天免疫系統(tǒng)中發(fā)揮調(diào)節(jié)作用,參與對(duì)其他生物體的防御響應(yīng)、基于免疫球蛋白超家族結(jié)構(gòu)域的免疫受體的體細(xì)胞重組的適應(yīng)性免疫應(yīng)答的正調(diào)控,以及細(xì)胞因子生產(chǎn)的正調(diào)控。NLRP10與多種疾病相關(guān),包括Petrositis和神經(jīng)發(fā)育障礙伴不自主運(yùn)動(dòng)。

熱銷(xiāo)產(chǎn)品

NLRP10 Antibody (CSB-PA773044LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA773044LA01HU

Western Blot
Positive WB detected in: Rat heart tissue
All lanes: NLRP10 antibody at 4.9μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 76 kDa
Observed band size: 76 kDa

CSB-PA773044LA01HU

IHC image of CSB-PA773044LA01HU diluted at 1:400 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA773044LA01HU

Immunofluorescence staining of Hela cells with CSB-PA773044LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

NLRP10 Antibodies

NLRP10 for Homo sapiens (Human)

NLRP10 Proteins

NLRP10 Proteins for Homo sapiens (Human)