NLRP3
NLRP3，即含pyrin結(jié)構(gòu)域的NOD樣受體3，別名PYRIN-containing APAF1-like protein 1。它是一種多蛋白復(fù)合體，是固有免疫系統(tǒng)中的重要組成部分，主要在細(xì)胞質(zhì)中發(fā)揮作用。NLRP3炎性小體能夠識別各種病原體相關(guān)分子模式(PAMPs)和損傷相關(guān)分子模式(DAMPs)，激活后促進(jìn)半胱氨酸天冬氨酸特異性蛋白酶-1(caspase-1)的活化，進(jìn)而切割前體IL-1β和IL-18成為成熟形式，引發(fā)炎癥反應(yīng)。NLRP3炎性小體的生物學(xué)意義在于其在調(diào)節(jié)宿主免疫反應(yīng)中發(fā)揮的重要作用。它不僅參與機(jī)體對病原體的防御，還涉及多種炎癥性疾病的發(fā)生發(fā)展。NLRP3炎性小體的異常激活與多種疾病相關(guān)，包括膿毒癥、代謝性疾病、自身炎癥性疾病等。因此，NLRP3成為了炎癥性疾病治療的潛在靶點(diǎn)，針對NLRP3炎性小體的抑制劑正在被廣泛研究，以期開發(fā)出新的抗炎藥物。
熱銷產(chǎn)品
Recombinant Human NACHT, LRR and PYD domains-containing protein 3 (NLRP3), partial (CSB-EP822275HU2)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
NLRP3 Antibody (CSB-PA015871LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human bladder cancer using CSB-PA015871LA01HU at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA015871LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Mouse NACHT, LRR and PYD domains-containing protein 3(NLRP3) ELISA kit (CSB-EL015871MO)
驗(yàn)證數(shù)據(jù)
貨號：CSB-EL015871MO
規(guī)格：96T/48T
靈敏度：1.56 pg/mL
檢測范圍：6.25 pg/mL-400 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
NLRP3 Antibodies
NLRP3 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA005618 | NLRP3 Antibody | Human | WB, ELISA |
| CSB-PA084492 | NLRP3 Antibody | Human | ELISA,IHC |
| CSB-PA993403 | NLRP3 Antibody | Human | ELISA,WB |
| CSB-PA209407 | NLRP3 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA015871LA01HU | NLRP3 Antibody | Human | ELISA, IHC, IF |
| CSB-PA015871LB01HU | NLRP3 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA015871LC01HU | NLRP3 Antibody, FITC conjugated | Human | |
| CSB-PA015871LD01HU | NLRP3 Antibody, Biotin conjugated | Human | ELISA |
NLRP3 for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA823181LA01MO | Nlrp3 Antibody | Mouse | ELISA, IF |
| CSB-PA823181LB01MO | Nlrp3 Antibody, HRP conjugated | Mouse | ELISA |
| CSB-PA823181LC01MO | Nlrp3 Antibody, FITC conjugated | Mouse | |
| CSB-PA823181LD01MO | Nlrp3 Antibody, Biotin conjugated | Mouse | ELISA |
NLRP3 Proteins
NLRP3 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP015871BO CSB-EP015871BO CSB-BP015871BO CSB-MP015871BO CSB-EP015871BO-B |
Recombinant Bovine NACHT, LRR and PYD domains-containing protein 3 (NLRP3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NLRP3 Proteins for Macaca mulatta (Rhesus macaque)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP015871MOW CSB-EP015871MOW CSB-BP015871MOW CSB-MP015871MOW CSB-EP015871MOW-B |
Recombinant Macaca mulatta (Rhesus macaque) NACHT, LRR and PYD domains-containing protein 3 (NLRP3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NLRP3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP822275HU CSB-EP822275HU CSB-BP822275HU CSB-MP822275HU CSB-EP822275HU-B |
Recombinant Human NACHT, LRR and PYD domains-containing protein 3 (NLRP3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP822275HU1 | Recombinant Human NACHT, LRR and PYD domains-containing protein 3 (NLRP3), partial | E.coli |
| CSB-EP822275HU3 | Recombinant Human NACHT, LRR and PYD domains-containing protein 3 (NLRP3), partial | E.coli |
| CSB-EP822275HU2 | Recombinant Human NACHT, LRR and PYD domains-containing protein 3 (NLRP3), partial | E.coli |
| CSB-EP822275HU2a2 | Recombinant Human NACHT, LRR and PYD domains-containing protein 3 (NLRP3), partial | E.coli |
| CSB-EP822275HU7 | Recombinant Human NACHT, LRR and PYD domains-containing protein 3 (NLRP3), partial | E.coli |
NLRP3 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP823181MO CSB-BP823181MO CSB-MP823181MO CSB-EP823181MO-B |
Recombinant Mouse NACHT, LRR and PYD domains-containing protein 3 (Nlrp3), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP823181MO | Recombinant Mouse NACHT, LRR and PYD domains-containing protein 3 (Nlrp3), partial | E.coli |
NLRP3 ELISA Kit
NLRP3 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E15885h | Human NACHT, LRR and PYD domains-containing protein 3 (NLRP3/C1orf7/CIAS1/NALP3/PYPAF1) ELISA kit | serum, plasma, tissue homogenates | 0.039 ng/ml |
NLRP3 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL015871MO | Mouse NACHT, LRR and PYD domains-containing protein 3(NLRP3) ELISA kit | serum, plasma, tissue homogenates | 1.56 pg/mL |
