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NPHS1

NPHS1,別稱CNF、NPHN,是腎小球?yàn)V過屏障結(jié)構(gòu)中的關(guān)鍵蛋白,位于足細(xì)胞裂孔隔膜。該蛋白在維持腎小球?yàn)V過功能中起著至關(guān)重要的作用,其缺陷與芬蘭型先天性腎病綜合癥相關(guān),導(dǎo)致蛋白質(zhì)大量泄漏至尿液中,引發(fā)蛋白尿。NPHS1蛋白的表達(dá)和功能異常,不僅影響腎小球的正常過濾功能,還可能對(duì)心血管系統(tǒng)的發(fā)展造成影響。目前,針對(duì)NPHS1相關(guān)疾病的藥物研發(fā)主要集中在抗-Nephrin抗體,這類抗體在動(dòng)物模型中顯示出誘導(dǎo)蛋白尿和腎病綜合征的潛力。然而,在人體內(nèi)的應(yīng)用仍需謹(jǐn)慎評(píng)估,因?yàn)榭?Nephrin抗體可能成為腎移植后復(fù)發(fā)的發(fā)病機(jī)制之一。此外,對(duì)Nephrin蛋白不同表位和抗體的相互作用機(jī)制研究,以及開發(fā)針對(duì)抗-Nephrin抗體陽性患者的特異性藥物,是未來研究的重點(diǎn)方向。

熱銷產(chǎn)品

Recombinant Human Nephrin (NPHS1), partial (CSB-EP015988HU)

驗(yàn)證數(shù)據(jù)

CSB-EP015988HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

NPHS1 Antibody (CSB-PA015988LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA015988LA01HU

WPositive WB detected in: JK whole cell lysate30μg), U251 whole cell lysate(30μg), MCF7 whole cell lysate(30μg), 293T whole cell lysate(30μg)
All lanes: NPHS1 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 135,131 kDa
Observed band size: 135 kDa
Exposure time:120s

CSB-PA015988LA01HU

IHC image of CSB-PA015988LA01HU diluted at 1:100 and staining in paraffin-embedded human colorectal cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody

CSB-PA015988LA01HU

IHC image of CSB-PA015988LA01HU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody

Human Nephrin ELISA Kit (CSB-E09886h)

驗(yàn)證數(shù)據(jù)

CSB-E09886h 標(biāo)準(zhǔn)曲線

貨號(hào):CSB-E09886h

規(guī)格:96T/48T

靈敏度:0.39 ng/ml

檢測(cè)范圍:1.56 ng/ml-100ng/ml

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

NPHS1 Antibodies

NPHS1 for Homo sapiens (Human)

NPHS1 Proteins

NPHS1 Proteins for Homo sapiens (Human)

NPHS1 Proteins for Homo sapiens (Human)

NPHS1 ELISA Kit

NPHS1 ELISA Kit for Homo sapiens (Human)