NPM1
NPM1，即核磷酸蛋白1，別名B23、Numatrin。它是一種主要定位于細(xì)胞核仁中的多功能伴侶蛋白，在細(xì)胞核和細(xì)胞質(zhì)之間穿梭，參與細(xì)胞核糖體合成、中心體復(fù)制、DNA修復(fù)等過程。NPM1還與P53、ARF等蛋白共同調(diào)控細(xì)胞凋亡。其作用機(jī)制涉及與多種蛋白質(zhì)相互作用，影響細(xì)胞周期調(diào)控、細(xì)胞增殖、分化和凋亡。NPM1在多種惡性腫瘤細(xì)胞中高表達(dá)，如急性髓系白血病（AML），其突變形式與疾病的發(fā)病機(jī)制相關(guān)，可作為微小殘留?。∕RD）監(jiān)測的重要指標(biāo)。NPM1的異常表達(dá)或功能失調(diào)與腫瘤的發(fā)生發(fā)展密切相關(guān)，是研究和治療急性白血病等惡性腫瘤的關(guān)鍵靶點(diǎn)。
熱銷產(chǎn)品
Recombinant Human Nucleophosmin (NPM1) (CSB-EP015996HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
驗(yàn)證數(shù)據(jù)
Western Blot analysis of COS7 cells using Nucleophosmin Polyclonal Antibody
Western Blot analysis of 293 AD293 cells using Nucleophosmin Polyclonal Antibody
Human Nucleophosmin(NPM1) ELISA kit (CSB-EL015996HU)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-EL015996HU
規(guī)格：96T/48T
靈敏度：5.8 pg/mL
檢測范圍：23.5 pg/mL-1500 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
NPM1 Antibodies
NPM1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA015996GA01HU | NPM1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA582765 | Phospho-NPM1 (Thr199) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA003471 | NPM1 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA003492 | NPM1 Antibody | Human,Mouse,Rat,Monkey | WB, IHC, ELISA |
| CSB-PA020150 | Phospho-NPM1 (T234) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA020151 | Phospho-NPM1 (T199) Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA020152 | NPM1 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
NPM1 Proteins
NPM1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP015996RA CSB-EP015996RA CSB-BP015996RA CSB-MP015996RA CSB-EP015996RA-B |
Recombinant Rat Nucleophosmin (Npm1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NPM1 Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP015996CH CSB-EP015996CH CSB-BP015996CH CSB-MP015996CH CSB-EP015996CH-B |
Recombinant Chicken Nucleophosmin (NPM1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NPM1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP015996HU CSB-BP015996HU CSB-MP015996HU CSB-EP015996HU-B |
Recombinant Human Nucleophosmin (NPM1) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP015996HU | Recombinant Human Nucleophosmin (NPM1) | E.coli |
NPM1 Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP015996XBE CSB-EP015996XBE CSB-BP015996XBE CSB-MP015996XBE CSB-EP015996XBE-B |
Recombinant Xenopus laevis Nucleophosmin (npm1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NPM1 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP663615BO CSB-EP663615BO CSB-BP663615BO CSB-MP663615BO CSB-EP663615BO-B |
Recombinant Bovine Nucleophosmin (NPM1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NPM1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP737048MO CSB-BP737048MO CSB-MP737048MO CSB-EP737048MO-B |
Recombinant Mouse Nucleophosmin (Npm1) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP737048MO | Recombinant Mouse Nucleophosmin (Npm1) | E.coli |
NPM1 ELISA Kit
NPM1 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL015996HU | Human Nucleophosmin(NPM1) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 5.8 pg/mL |
