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NPR1

NPR1,全稱為利鈉肽受體1(Natriuretic Peptide Receptor 1),也被稱為利鈉肽受體A型(NPR-A)。該蛋白主要參與心血管系統(tǒng)的調(diào)節(jié),對(duì)血壓和靜脈張力有重要影響。NPR1蛋白能夠與心房利鈉肽(ANP)和腦利鈉肽(BNP)結(jié)合,激活下游信號(hào)通路,促進(jìn)血管舒張、利尿排鈉和降低血壓。NPR1蛋白在心力衰竭的治療中具有巨大潛力,相關(guān)藥物如REGN5381和XXB750等,通過激活NPR1蛋白,能夠有效降低靜脈壓力,改善心力衰竭患者的血液動(dòng)力學(xué)狀態(tài)。此外,NPR1蛋白還與腎臟疾病相關(guān),研究表明,靶向NPR1蛋白的治療策略能夠改善腎臟損傷和纖維化。目前,針對(duì)NPR1蛋白的藥物研發(fā)仍在進(jìn)行中,未來有望為心血管疾病和腎臟疾病患者帶來新的治療選擇。

熱銷產(chǎn)品

Recombinant Human Atrial natriuretic peptide receptor 1 (NPR1), partial (CSB-EP016023HUc7)

驗(yàn)證數(shù)據(jù)

CSB-EP016023HUc7

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

NPR1 Antibody (CSB-PA934625)

驗(yàn)證數(shù)據(jù)

CSB-PA934625

The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA934625(NPR1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)

CSB-PA934625

The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA934625(NPR1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)

NPR1 Antibodies

NPR1 for Homo sapiens (Human)

NPR1 Proteins

NPR1 Proteins for Mus musculus (Mouse)

NPR1 Proteins for Homo sapiens (Human)

NPR1 Proteins for Rattus norvegicus (Rat)

NPR1 Proteins for Arabidopsis thaliana (Mouse-ear cress)

NPR1 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)