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NR3C1

NR3C1,別名GRL、GCCR。這個(gè)基因位于人類(lèi)第5號(hào)染色體上,編碼的糖皮質(zhì)激素受體在體內(nèi)幾乎每個(gè)細(xì)胞中都有表達(dá),并且調(diào)節(jié)控制發(fā)育、新陳代謝和免疫反應(yīng)的基因。NR3C1的作用機(jī)制是通過(guò)與糖皮質(zhì)激素如皮質(zhì)醇結(jié)合,調(diào)節(jié)基因轉(zhuǎn)錄。未結(jié)合的受體存在于細(xì)胞的胞質(zhì)溶膠中,與糖皮質(zhì)激素結(jié)合后,受體-激素復(fù)合物可以進(jìn)入細(xì)胞核,通過(guò)反式激活或反式抑制的方式調(diào)節(jié)基因表達(dá)。NR3C1在應(yīng)對(duì)壓力源的短期和長(zhǎng)期適應(yīng)中發(fā)揮作用,可能對(duì)理解心理障礙,包括抑郁癥和創(chuàng)傷后應(yīng)激障礙(PTSD)的某些或所有亞型至關(guān)重要。此外,NR3C1的異常表達(dá)與多種疾病的發(fā)生發(fā)展相關(guān),如自身免疫疾病、代謝性疾病以及某些癌癥。

熱銷(xiāo)產(chǎn)品

Recombinant Human Glucocorticoid receptor (NR3C1), partial (CSB-EP016059HU1c2)

驗(yàn)證數(shù)據(jù)

CSB-EP016059HU1c2

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

NR3C1 Recombinant Monoclonal Antibody (CSB-RA958910A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA958910A0HU

Western Blot
Positive WB detected in: 293 whole cell lysate, Hela whole cell lysate, HepG2 whole cell lysate, Jurkat whole cell lysate, A549 whole cell lysate, MCF-7 whole cell lysate, U87 whole cell lysate
All lanes: NR3C1 antibody at 1:1500
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 86, 83, 82, 77, 76, 65, 61, 52, 51, 50 kDa
Observed band size: 95 kDa

CSB-RA958910A0HU

Overlay histogram showing Jurkat cells stained with CSB-RA958910A0HU (red line) at 1:50. The cells were fixed with 70% Ethylalcohol (18h) and then incubated in 10% normal goat serum to block non-specific protein-protein interactions followedby the antibody (1μg/1*106 cells) for 1 h at 4℃.The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 30min at 4℃. Control antibody (green line) was Rabbit IgG (1μg/1*106 cells) used under the same conditions. Acquisition of >10,000 events was performed.

Human Glucocorticoid receptor(NR3C1) ELISA kit (CSB-EL016059HU)

驗(yàn)證數(shù)據(jù)

CSB-EL016059HU 標(biāo)準(zhǔn)曲線

貨號(hào):CSB-EL016059HU

規(guī)格:96T/48T

靈敏度:7.81 pg/mL

檢測(cè)范圍:31.25 pg/mL-2000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

NR3C1 Antibodies

NR3C1 for Homo sapiens (Human)

NR3C1 Proteins

NR3C1 Proteins for Homo sapiens (Human)

NR3C1 ELISA Kit

NR3C1 ELISA Kit for Homo sapiens (Human)