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NUCB2

NUCB2,即核結(jié)合蛋白2,別名NEFA、HEL-S-109。NUCB2屬于核結(jié)合蛋白家族,具有EF-hand結(jié)構(gòu)域,能夠結(jié)合鈣離子。NUCB2在鈣水平維持、下丘腦進(jìn)食調(diào)節(jié)以及血管內(nèi)皮細(xì)胞釋放腫瘤壞死因子等方面發(fā)揮作用。這種蛋白質(zhì)通過其EF-hand結(jié)構(gòu)域結(jié)合鈣離子,參與細(xì)胞內(nèi)信號傳導(dǎo)和基因表達(dá)的調(diào)控。NUCB2在多種生理過程中起作用,包括能量代謝、食欲調(diào)節(jié)以及可能與腫瘤發(fā)生發(fā)展相關(guān)。NUCB2的基因產(chǎn)物可以被剪切成幾種不同的肽產(chǎn)品,其中Nesfatin-1被發(fā)現(xiàn)能夠獨(dú)立于瘦素抑制食物攝入,并且可能在能量平衡和神經(jīng)內(nèi)分泌功能中發(fā)揮作用。

熱銷產(chǎn)品

Recombinant Human Nucleobindin-2 (NUCB2) (CSB-EP016146HU)

驗證數(shù)據(jù)

CSB-EP016146HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

NUCB2 Antibody (CSB-PA016146HA01HU)

驗證數(shù)據(jù)

CSB-PA016146HA01HU

Western Blot
Positive WB detected in: Rat brain tissue, Rat heart tissue, Mouse heart tissue, Mouse liver tissue, Mouse brain tissue
All lanes: NUCB2 antibody at 2.5μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 51 kDa
Observed band size: 51 kDa

CSB-PA016146HA01HU

IHC image of CSB-PA016146HA01HU diluted at 1:200 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA016146HA01HU

IHC image of CSB-PA016146HA01HU diluted at 1:200 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

NUCB2 Antibodies

NUCB2 for Homo sapiens (Human)

NUCB2 Proteins

NUCB2 Proteins for Homo sapiens (Human)