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OPRM1

OPRM1,即μ型阿片受體(mu opioid receptor),也稱為MOR。該受體是人體內(nèi)源性阿片肽的主要靶點,參與疼痛感知、情緒調(diào)節(jié)和成癮等生理過程。μ型阿片受體屬于G蛋白偶聯(lián)受體超家族,具有7次跨膜結(jié)構(gòu),通過與內(nèi)源性阿片肽或外源性阿片類藥物結(jié)合,激活下游信號通路,影響神經(jīng)元的活動。
μ型阿片受體在多種生理和病理過程中發(fā)揮重要作用。例如,內(nèi)源性阿片肽如β-內(nèi)啡肽和腦啡肽與其結(jié)合后,可以產(chǎn)生鎮(zhèn)痛、欣快感等效應。μ型阿片受體也參與成癮的發(fā)生,長期使用阿片類藥物會導致μ型阿片受體表達下調(diào)或功能改變,從而產(chǎn)生耐受性和依賴性。此外,μ型阿片受體還與多種疾病相關,如慢性疼痛、焦慮癥、抑郁癥等。
由于μ型阿片受體在疼痛治療和成癮方面的作用,成為藥物研發(fā)的重要靶點。目前,已有多種μ型阿片受體激動劑和拮抗劑被開發(fā)出來,用于鎮(zhèn)痛和治療成癮性疾病。例如,嗎啡、海洛因等阿片類藥物是μ型阿片受體激動劑,可以產(chǎn)生強大的鎮(zhèn)痛效果,但也容易導致成癮。而納洛酮等μ型阿片受體拮抗劑則可以用于治療阿片類藥物成癮。此外,研究人員也在探索靶向μ型阿片受體的新型藥物,以期提高療效并降低副作用。

熱銷產(chǎn)品

Recombinant Human Mu-type opioid receptor (OPRM1) (CSB-CF016361HU)

驗證數(shù)據(jù)

CSB-CF016361HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

OPRM1 Antibody (CSB-PA016361LA01HU)

驗證數(shù)據(jù)

CSB-PA016361LA01HU

Western Blot
Positive WB detected in: SH-SY5Y whole cell lysate
All lanes: OPRM1 antibody at 2.9µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 45, 44, 50, 48, 46, 56, 35, 37, 34, 14, 11, 21 kDa
Observed band size: 45 kDa

CSB-PA016361LA01HU

IHC image of CSB-PA016361LA01HU diluted at 1:500 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA016361LA01HU

Immunofluorescence staining of HepG2 cells with CSB-PA016361LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Human Mu-type opioid receptor(OPRM1) ELISA kit (CSB-EL016361HU)

驗證數(shù)據(jù)

CSB-EL016361HU 標準曲線

貨號:CSB-EL016361HU

規(guī)格:96T/48T

靈敏度:7.81 pg/mL

檢測范圍:31.25 pg/mL-2000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

OPRM1 Antibodies

OPRM1 for Homo sapiens (Human)

OPRM1 Proteins

OPRM1 Proteins for Bos taurus (Bovine)

OPRM1 Proteins for Cavia porcellus (Guinea pig)

OPRM1 Proteins for Homo sapiens (Human)

OPRM1 Proteins for Mus musculus (Mouse)

OPRM1 Proteins for Rattus norvegicus (Rat)

OPRM1 Proteins for Saimiri boliviensis boliviensis (Bolivian squirrel monkey)

OPRM1 Proteins for Pan troglodytes (Chimpanzee)

OPRM1 Proteins for Sus scrofa (Pig)

OPRM1 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

OPRM1 Proteins for Macaca mulatta (Rhesus macaque)

OPRM1 ELISA Kit

OPRM1 ELISA Kit for Homo sapiens (Human)